Results 91 to 100 of about 2,826,501 (343)

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The death of cost-minimization analysis? [PDF]

, 2001
Four different types of evaluation methods, cost-benefit analysis (CBA), cost-utility analysis (CUA), cost-effectiveness analysis (CEA) and cost-minimization analysis (CMA), are usually distinguished. In this note, we pronounce the (near) death of CMA by
Altman, Briggs, Connolly, Connolly, Donaldson, Drummond, Drummond, Freiman, Gold, Kuck, Laska, O'Brien, O'Brien, Robinson, Robinson, Robinson, Robinson, Senn, Stinnett, Stinnett, Tambour, van Hout   +21 more
core   +2 more sources

Econometric estimation of country-specific hospital costs

Cost Effectiveness and Resource Allocation, 2003
Information on the unit cost of inpatient and outpatient care is an essential element for costing, budgeting and economic-evaluation exercises. Many countries lack reliable estimates, however.
Murray Christopher JL, Evans David B, Adam Taghreed   +2 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The effectiveness and cost-effectiveness of respite for caregivers of frail older people [PDF]

, 2007
The proportion of frail elderly people in the industrialized world is increasing. Respite care is a potentially important way of maintaining the quality of life for these people and their caregivers.
Arksey, Artaso Irigoyen, Baumgarten, Buchner, Burch, Census 2001., Chapko, Clark, Conlin, Covinsky, Derogatis, Donaldson, Feinberg, Fisher, Gaugler, Gaugler, Grant, Grundy, Hedrick, Hirst, Holm, Johnson, Kosloski, Kosloski, Lawton, Lee, Lund, Maher, Montgomery, Montgomery, Montgomery, Montgomery, Montgomery, Niebuhr, Pinquart, Quayhagen, Robertson, Robertson, Rockwood, Rockwood, Rockwood, Sörensen, Undertaking Systematic Reviews of Research on Effectiveness., Walston, Wan, Wells, Wills, Wishart, Yin, Zank, Zarit   +50 more
core   +1 more source

Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach

Cost Effectiveness and Resource Allocation, 2010
Background Economic evaluation of stroke services indicates that such services may lead to improved quality of life at affordable cost. The present study assesses lifetime health impact and cost consequences of stroke in an integrated service setting ...
Dirks Maaike, van Exel N Job A, Baeten Stefan A, Koopmanschap Marc A, Dippel Diederik WJ, Niessen Louis W   +5 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Cost-Effectiveness of Rotavirus Vaccination in France-Accounting for Indirect Protection. [PDF]

, 2016
BACKGROUND: Vaccination against rotavirus has shown great potential for reducing the primary cause of severe childhood gastroenteritis. Previous economic evaluations of rotavirus vaccination in France have not modeled the potential impact of vaccines on ...
Atkins, Katherine E, Galvani, Alison P, Remy, Vanessa, Yamin, Dan   +3 more
core   +1 more source

Combining multicriteria decision analysis, ethics and health technology assessment: applying the EVIDEM decisionmaking framework to growth hormone for Turner syndrome patients

Cost Effectiveness and Resource Allocation, 2010
Objectives To test and further develop a healthcare policy and clinical decision support framework using growth hormone (GH) for Turner syndrome (TS) as a complex case study.
Grégoire Jean-Pierre, Rindress Donna, Khoury Hanane, Wagner Monika, Goetghebeur Mireille M, Deal Cheri   +5 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source