Results 61 to 70 of about 2,987,019 (361)

Is primary angioplasty cost effective in the UK? Results of a comprehensive decision analysis [PDF]

, 2007
Objective: To assess the cost effectiveness of primary angioplasty, compared with medical management with thrombolytic drugs, to achieve reperfusion after acute myocardial infarction ( AMI) from the perspective of the UK NHS.
Abrams, Keith, Asseburg, Christian, de Belder, Mark, Fenwick, Elisabeth, Palmer, Stephen, Sculpher, Mark, Vergel, Yolanda Bravo   +6 more
core   +2 more sources

Cost-effectiveness of algorithms [PDF]

Discrete Mathematics & Theoretical Computer Science, 2015
Discrete Algorithms In this paper we discuss how to assess the performance of algorithms for optimisation problems in a way that balances solution quality and time. We propose measures of cost-effectiveness for such algorithms. These measures give the gain in solution quality per time unit over a sequence of inputs, and give a basis for ...
openaire   +4 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

The cost-effectiveness of standalone HEPA filtration units for the prevention of airborne SARS CoV-2 transmission

Cost Effectiveness and Resource Allocation, 2022
Objective Airborne infection from aerosolized SARS-CoV-2 poses an economic challenge for businesses without existing heating, ventilation, and air conditioning (HVAC) systems. The Environmental Protection Agency notes that standalone units may be used in
Zafar Zafari, Pedro M. de Oliveira, Savvas Gkantonas, Chinenye Ezeh, Peter Alexander Muennig   +4 more
doaj   +1 more source

Using cost effectiveness analysis; a beginners guide [PDF]

, 2006
Objective ‐ This report seeks to describe the key elements of cost effectiveness analysis (CEA) and to demonstrate how such analysis may be used in the library environment. Methods ‐ The paper uses a step‐by‐step approach to walk the non‐economist
Hulme, C.
core   +1 more source

Pressure relieving support surfaces (PRESSURE) trial : cost effectiveness analysis [PDF]

, 2006
Objective To assess tire cost effectiveness of alternating pressure mattresses compared with alternating pressure overlays for the prevention of pressure ulcers in patients admitted to hospital.
Cranny, Gillian, Cullum, Nicky, Grp, PRESSURE Trial, Hawkins, Kim, Iglesias, Cynthia, Mason, Su, Nelson, E Andrea, Nixon, Jane, Phillips, Angela, Torgerson, David   +9 more
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Economics of tandem mass spectrometry screening of neonatal inherited disorders [PDF]

, 2006
Objectives: The aim of this study was to evaluate the cost-effectiveness of neonatal screening for phenylketonuria (PKU) and medium-chain acyl-coA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (tandem MS). Methods: A systematic review
Beverley, C., Chilcott, J., Eastham, J., Paisley, S., Pandor, A.   +4 more
core   +1 more source

Costs, effects and cost‐effectiveness of breast cancer control in Ghana [PDF]

Tropical Medicine & International Health, 2012
AbstractObjective  Breast cancer control in Ghana is characterised by low awareness, late‐stage treatment and poor survival. In settings with severely constrained health resources, there is a need to spend money wisely. To achieve this and to guide policy makers in their selection of interventions, this study systematically compares costs and effects ...
Laurens M. Niëns, Moses Aikins, Jeremy A. Lauer, Jan A. C. Hontelez, Jan A. C. Hontelez, Cecilia Sepulveda, Rob Baltussen, Kofi Mensah Nyarko, Sten G. Zelle, William K. Bosu   +9 more
openaire   +4 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source