Results 91 to 100 of about 28,214,434 (299)

Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis [PDF]

, 2002
<b>Objective</b>: To compare the cost and cost-effectiveness of a policy of pre-operative optimisation of oxygen delivery (using either adrenaline or dopexamine) to reduce the risk associated with major elective surgery, in high-risk patients.
Sculpher, M.J., Fenwick, E., Claxton, K., Wilson, J.   +3 more
core   +1 more source

Cost-effectiveness acceptability curves from probabilistic sensitivity analysis.

, 2023
Cost-effectiveness acceptability curves from probabilistic sensitivity analysis.
Coline Dubois de Gennes (14445446), Clément Le Dissez (14445455), Pierre Nahon (524636), Benjamin Mazaleyrat (14445452), Hélène Cawston (841327), Javier Sanchez Alvares (14445449), Loïg Gaugain (14445443)   +6 more
core   +1 more source

Paying for cost-effective health care: Does it violate both static- and dynamic efficiency?

Nordic Journal of Health Economics, 2015
Recent research has questioned the rationales of using cost-effectiveness metrics of medical technologies to guide reimbursement. I discuss here the underlying ideas of this research, which argues that reimbursement based on cost effectiveness criteria ...
Tomas J Philipson
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Prevention and treatment of cardiovascular disease in Ethiopia: a cost-effectiveness analysis [PDF]

, 2016
Background: The coverage of prevention and treatment strategies for ischemic heart disease and stroke is very low in Ethiopia. In view of Ethiopia’s meager healthcare budget, it is important to identify the most cost-effective interventions for further ...
Strand, Kirsten, Senbeta Guteta Abdisa, Tolla, Mieraf Taddesse, Mieraf Taddesse Tolla, Awel Ababulgu, Melanie Bertram, Abdisa, Senbeta Guteta, Bertram, Melanie, Ole Frithjof Norheim, Degu Jerene, Stéphane Verguet, Johansson, Kjell Arne, Memirie, Solomon Tessema, Verguet, Stéphane, Kirsten Strand, Norheim, Ole Frithjof, Ababulgu, Awel, Kjell Arne Johansson, Jerene, Degu, Solomon Tessema Memirie   +19 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Endogenous Cost-Effectiveness Analysis in Health Care Technology Adoption [PDF]

Increased health care spending has been argued to be largely due to technological change. Cost-effectiveness analysis is the main tool used by private and public third-party payers to prioritize adoption of the new technologies responsible for this ...
Tomas Philipson, Anupam Jena
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Cost-effectiveness analysis and its application for policy evaluation for medicine or public health [PDF]

In comparison to the policy for other field, the policy for medicine and public health is to consider the value of life or the value of the quality of life. Quality of life is very well known as a concept of QOL.
Tamie Sugawara, Yasushi Ohkusa
core