Results 41 to 50 of about 618,094 (183)

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Donor-Site Morbidity Following Minimally Invasive Costal Cartilage Harvest Technique [PDF]

, 2015
ObjectivesAutologous costal cartilage is a promising alternative for mastoid obliteration. However, donor-site morbidities of the chest wall limit the use of this graft.
Yong Beom Cho, Si Young Jo, Chul Ho Jang, Hyung Chae Yang, Hyong-Ho Cho   +4 more
core   +2 more sources

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Machine Learning‐Enabled Field Prediction and Inverse Design of Functionally Graded Materials Inspired by Tendon–Bone Enthesis

Advanced Intelligent Systems, EarlyView.
A mechanics‐informed machine learning framework enables mechanics field prediction and inverse design of tendon–bone enthesis‐inspired functionally graded materials that reduce stress concentration and failure risk. By coupling multiscale finite element modeling, convolutional field prediction, and kernel‐based inverse design, the study uncovers ...
Zhangke Yang, Zhaoxu Meng
wiley   +1 more source

Determining the Most Suitable Costal Cartilage Level for Rhinoplasty

, 2011
Objective. The aim of this study was to compare the biomechanical properties of septal cartilage (SC) and costal cartilage (CC) grafts harvested from different ribs and to find at which level CC has characteristics closest to ...
Acıoğlu, Engin, ÜNAL, Ahmet, Alkan, Zeynep, Şahin, Feyzi, Yiğit, Ozgur, BEKEM, Aylin, Azizli, Elad, Elad Azizli, Ozgur Yigit, Zeynep Alkan, Ahmet Unal, Aylin Bekem, Feyzi Sahin, Engin Acioglu   +13 more
core   +1 more source

Born this way: Does variation in perinatal limb bone morphology predict adult locomotor repertoire in primates?

The Anatomical Record, EarlyView.
Abstract Primates show a high degree of locomotor diversity that engenders similar variance in limb bone cross‐sectional geometry and bending strength: leaping primates have stronger hindlimb bones whereas suspensory species have stronger forelimb bones.
Angela M. Mossor, Jeremy Busken, Lorna Benden, Ethan Mardovin, Andrew Bostick, Grégoire Boulinguez‐Ambroise, Timothy D. Smith, Jesse W. Young   +7 more
wiley   +1 more source

Decorin Expression, Straw-Like Structure, and Differentiation of Human Costal Cartilage [PDF]

, 2012
Costal cartilage is much understudied compared with the load-bearing cartilages. Abnormally grown costal cartilages are associated with the inherited chest wall deformities pectus excavatum and pectus carinatum resulting in sunken and pigeon chests ...
Fecteau, Annie, Beskok, Ali, Pryor, Julie, Stacey, Michael W., Darby, Dennis A., Werner, Alice, Asmar, Anthony, Elsayed-Ali, Hani, Grubb, Janna, Dutta, Diganta, Kelly, Robert   +10 more
core   +1 more source

Scaling and ecomorphology of lagomorph body shape and appendicular skeleton

The Anatomical Record, EarlyView.
Abstract Body shape is one of the most prominent features of phenotypic variation. Yet, mammalian body shapes are poorly quantified and the underlying components contributing to its diversity and its relationship to other skeletal components are rarely tested.
Nia Brice, Coby Huizenga, Chris J. Law
wiley   +1 more source