Results 91 to 100 of about 5,884 (248)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Prevalencia de úlceras por presión en una zona básica de salud

open access: yesGerokomos
Introducción: Las úlceras por presión (UPP) representan un importante problema de salud en todos los niveles asistenciales, pero un volumen importante de las mismas precisan de cuidados continuados desde la comunidad.
Juan de Con Redondo   +1 more
doaj  

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

La farmacoeconomía en la farmacia comunitaria

open access: yesFarmacéuticos Comunitarios, 2010
Las autoridades sanitarias están centradas en el denominado gasto farmacéutico y adoptan constantemente medidas de carácter economicista exclusivo con el fin de reducir los costes de los medicamentos.
Sanz GAA.
doaj  

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Los costes socioeconómicos de las enfermedades cardiovasculares y del cáncer en las Islas Canarias en 1998

open access: yesGaceta Sanitaria, 2003
Objetivo: Evaluar el impacto económico, en términos de costes directos e indirectos, de las enfermedades cardiovasculares y del cáncer, en Canarias, durante el año 1998. Métodos: El enfoque que se ha utilizado es el método del coste de la enfermedad. Los
López-Bastida J.   +2 more
doaj  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Controlar los costes e incentivar la eficiencia. La necesidad de evaluación objetiva de la enseñanza obligatoria

open access: yesRevista Española de Pedagogía
Este artículo considera la necesidad de controlar los costes y fomentar la eficiencia en la actividad educativa. Los fondos son escasos y, en esta situación, es esencial tener un uso eficiente de los mismos.
María Jesús San Segundo
doaj  

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