Dietary Supplementation of Novel Aflatoxin Oxidase CotA Alleviates Aflatoxin B1-Induced Oxidative Stress, Lipid Metabolism Disorder, and Apoptosis in the Liver of Japanese Quails [PDF]
AnimalsThis research explored the role of aflatoxin oxidase CotA in mitigating aflatoxin B1 (AFB1)-induced hepatotoxicity in Japanese quails. A total of 225 female Japanese quails, aged two weeks, were randomly assigned to three dietary groups: a control diet ...
Hao Lv +6 more
doaj +3 more sources
Enzymatic Oxidation of Aflatoxin M1 in Milk Using CotA Laccase [PDF]
FoodsAflatoxin M1 (AFM1) in milk poses a significant threat to human health. This study examined the capacity of Bacillus licheniformis CotA laccase to oxidize AFM1.
Yongpeng Guo +6 more
doaj +3 more sources
Bacillus CotA laccase improved the intestinal health, amino acid metabolism and hepatic metabolic capacity of Pekin ducks fed naturally contaminated AFB1 diet [PDF]
Journal of Animal Science and BiotechnologyBackground Aflatoxin B1 (AFB1) is a prevalent contaminant in agricultural products, presenting significant risks to animal health. CotA laccase from Bacillus licheniformis has shown significant efficacy in degrading mycotoxins in vitro test. The efficacy
Mingxin Ma +10 more
doaj +3 more sources
Improvement of aflatoxin B1 degradation ability by Bacillus licheniformis CotA-laccase Q441A mutant
Heliyon, 2023 Aflatoxin B1 (AFB1) contamination seriously threatens nutritional safety and common health. Bacterial CotA-laccases have great potential to degrade AFB1 without redox mediators.
Yanrong Liu +6 more
doaj +2 more sources
Characterization of an alkali- and halide-resistant laccase expressed in E. coli: CotA from Bacillus clausii. [PDF]
PLoS ONE, 2014 The limitations of fungal laccases at higher pH and salt concentrations have intensified the search for new extremophilic bacterial laccases. We report the cloning, expression, and characterization of the bacterial cotA from Bacillus clausii, a supposed ...
Søren Brander +2 more
doaj +6 more sources
COTA: Improving the Speed and Accuracy of Customer Support through Ranking and Deep Networks [PDF]
Knowledge Discovery and Data Mining, 2018 For a company looking to provide delightful user experiences, it is of paramount importance to take care of any customer issues. This paper proposes COTA, a system to improve speed and reliability of customer support for end users through automated ...
Bahdanau Dzmitry +10 more
core +2 more sources
Structured Promoter Variability in Epigenetically Regulated Operons Contributes to Surface Adaptation in Salmonella [PDF]
Microb BiotechnolWe discovered that Salmonella uses structured, recurrent variation in epigenetically regulated promoter regions to fine‐tune gene expression, revealing a novel evolutionary strategy for surface adaptation. ABSTRACT Bacterial adaptation to dynamic and hostile environments often relies on the ability to modify surface structures, which are subjected to ...
Fernández‐Fernández R +5 more
europepmc +2 more sources
Textile Dye Decolorizing Synechococcus PCC7942 Engineered With CotA Laccase
Frontiers in Bioengineering and Biotechnology, 2018 Cyanobacteria are prokaryotic phototrophs capable of achieving high cellular densities with minimal inputs. These prokaryotic organisms can grow using sunlight as energy source and carbon dioxide as carbon source what makes them promising candidates as ...
Yuanmei Liang +7 more
doaj +2 more sources
A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity [PDF]
Nature CommunicationsFungal pathogens must exhibit strong nutritional plasticity, effectively sensing and utilizing diverse nutrients to support virulence. How the signals generated by nutritional sensing are efficiently translated to the morphogenetic machinery for optimal ...
Adela Martin-Vicente +7 more
doaj +2 more sources