Results 51 to 60 of about 6,595 (179)

Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity‐Dependent in Adult Rats

Glia, Volume 74, Issue 8, August 2026.
In adulthood, astrocytic mGluR5 increases synaptic efficacy through presynaptic A2ARs. This occurs when a small number of synapses are activated simultaneously. This pathway is abolished when numerous synapses are recruited. ABSTRACT Data accumulated over the last two decades have demonstrated that astrocytes play key roles in the regulation of ...
Sarah Mountadem, Muna L. Hilal, Dylan Pommier, Dorian Arnouil, Valentin Clément Langlais, Vincent Simon, Aurélie Amadio, Marie Miegebielle, Sébastien Marais, Charlène Joséphine, Astrid Cannich, Marjorie Varilh, Julien Bourel, Daniela Cota, Giovanni Marsicano, Alexis‐Pierre Bemelmans, Philippe Ciofi, Stéphane Henri Richard Oliet, Aude Panatier   +18 more
wiley   +1 more source

Real‐world patient characteristics, treatment patterns, and treatment outcomes of patients with diffuse large B‐cell lymphoma by line of therapy

Cancer Medicine
Background Although initial treatment of diffuse large B‐cell lymphoma (DLBCL) with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) can be effective, up to 50% of patients will develop refractory or relapsed (R/R) disease ...
Helmneh M. Sineshaw, Christina M. Zettler, Jennifer Prescott, Mahek Garg, Samhita Chakraborty, Eric M. Sarpong, Claire Bai, Andrew J. Belli, Laura L. Fernandes, Ching‐Kun Wang   +9 more
doaj   +1 more source

Impacto da lei complementar 126/2006 nos resultados dos processos de aquisição de medicamentos e material médicohospitalar do município de Recife

Jornal de Assistência Farmacêutica e Farmacoeconomia
 Introdução: A Lei Complementar 123/2006 (LC 126/06) estabelece normas gerais relativas ao tratamento diferenciado e favorecido às microempresas e empresas de pequeno porte (MEEPP) no âmbito da União, dos Estados, do Distrito Federal e dos Municípios ...
Karinna Moura Boaviagem , Fitz Tenório, Cecília Leal, Ana Karla da Silva   +3 more
doaj   +1 more source

GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1–cAMP/PKA Pathway in the Cross‐Kingdom Biofilms

Molecular Oral Microbiology, Volume 41, Issue 4, Page 188-200, August 2026.
ABSTRACT The dual‐species biofilms formed by Streptococcus mutans and Candida albicans exhibit enhanced cariogenic potential due to the production of extracellular polysaccharides (EPSs). The response regulator GcrR in S. mutans negatively regulates EPS synthesis, but its impact on dual‐species biofilms remains unclear.
Bin Zhang, Shihao Hou, Anqi Zhang, Jielin Yang, Wenjiao Zhang, Shijie Zhu, Hong Chen, Ruizhe Huang   +7 more
wiley   +1 more source

Elranatamab in Relapsed/Refractory Multiple Myeloma: Mechanisms, Clinical Evidence, and Emerging Perspectives

European Journal of Haematology, Volume 117, Issue 1, Page 42-54, July 2026.
ABSTRACT Relapsed and refractory multiple myeloma (RRMM) remains associated with poor outcomes, particularly in patients exposed or refractory to proteasome inhibitors, immunomodulatory agents, and anti‐CD38 monoclonal antibodies. Targeting B‐cell maturation antigen (BCMA) has emerged as an effective therapeutic strategy, prompting the development of ...
Maria Eugenia Alvaro, Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Advancing Ecological Understanding and Sustainable Management of Small Pelagic Fish

Fish and Fisheries, Volume 27, Issue 4, Page 850-864, July 2026.
ABSTRACT Small pelagic fish (SPF) are critical to the trophodynamic structure and function of marine systems and support some of the most valuable and socially important fisheries worldwide. Their “boom and bust” population dynamics, shifts in distribution, and importance as forage resources for other fish stocks place unique challenges to assessing ...
Myron A. Peck, Ignacio A. Catalán, Ryan R. Rykaczewski, Akinori Takasuka, Susana Garrido, Rebecca G. Asch, Matthew R. Baker, Noelle M. Bowlin, Jennifer Boldt, Richard D. Brodeur, Cecilie Hansen, Salvador E. Lluch‐Cota, Martin Huret, Francis Juanes, Isaac C. Kaplan, Stefan Koenigstein, Marta Moyano, Rubén Rodríguez‐Sánchez, Christopher N. Rooper, Dongwha Sohn, Motomitsu Takahashi, Desiree Tommasi, Robert P. Wildermuth   +22 more
wiley   +1 more source

Cota não é Esmola

Revista Ágora Filosófica, 2022
O presente artigo carrega como objetivo a compreensão do discurso antirracista na obra “Cota não é esmola”, da cantora e compositora Bia Ferreira, sob a luz dos Estudos Discursivos Críticos, e como esse discurso interage com o discurso hegemônico racista.
Viviane Cristina Vieira, Johan Gabriel Capucho Von Behr, Fernando Fidelix Nunes, Juliana Harumi Chinatti Yamanaka   +3 more
openaire   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Structural and Functional Effects of Traditional Chuño Processing on Potato Starch (Solanum spp.)

Foods
Potato starch (Solanum spp.) undergoes structural and functional modifications during traditional Andean chuño production; however, the integrated effects of processing history, cultivar-associated characteristics, and field-based environmental ...
Fabiola Valdivieso, José Luis Vila, Patricia Mollinedo, Luis Apaza Ticona   +3 more
doaj   +1 more source

Impact of rotavirus vaccination on child mortality, morbidity, and rotavirus-related hospitalizations in Bolivia

International Journal of Infectious Diseases, 2017
Background: The public health impact of rotavirus vaccination in countries with high child mortality rates remains to be established. The RV1 rotavirus vaccine was introduced in Bolivia in August 2008.
Lucia Inchauste, Maritza Patzi, Kjetil Halvorsen, Susana Solano, Raul Montesano, Volga Iñiguez   +5 more
doaj   +1 more source