Results 321 to 330 of about 62,786 (347)

MOLECULAR ASPECTS OF SUGAR:ION COTRANSPORT

Annual Review of Biochemistry, 1986
INTRODUCTION .... . . . . . . . .. . COTRANSPORTERS .... . . .... .. . COTRANSPORT IN THEORy . . . . . ....... . . . . ... . . . . . . . . . . . ....... . . . . . . . .. . .... . . . .... . COTRANSPORT IN PRACTICE . . . . . . . . . . . . . ....... .. . . . . . . . . . .. ... . . .. .. . . . . ... .. . . . . . . .. ...... .
Robert Seckler, Peter Overath, J. Keith Wright   +2 more
openaire   +3 more sources

The Electroneutral Cation–Chloride Cotransporters

Journal of Experimental Biology, 1998
ABSTRACT Electroneutral cation–chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+–Cl− transporter, two Na+–K+–2Cl− transporters and two K+–Cl− cotransporters, encodes these membrane proteins; homologous genes have also been identified in a ...
Gerardo Gamba, R S Hoover, Eric Delpire, David B. Mount, E Poch, A E Hall, Steven C. Hebert   +6 more
openaire   +3 more sources

Sodium‐glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter‐organ crosstalk

Diabetes, obesity and metabolism, 2019
To investigate sodium‐glucose cotransporter 2 inhibitor (SGLT2i)‐induced changes in ketogenic enzymes and transporters in normal and diabetic mice models.
Jin Hee Kim, Minyoung Lee, S. H. Kim, So Ra Kim, Byung-wan Lee, E. Kang, B. Cha, J. Cho, Yong‐ho Lee   +8 more
semanticscholar   +1 more source

Cotransporters, WNKs and hypertension: an update

Current Opinion in Nephrology & Hypertension, 2008
Studies of inherited conditions characterized by high or low blood pressure reveal the importance of a new signalling cascade, With no Lysine kinases (WNK) --> ste20/SPS1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase-1 (OSR1) --> Cation-Chloride Cotransporters (CCC), in regulating blood pressure and in the pathogenesis ...
openaire   +2 more sources

Na+-K+-2Cl− Cotransporter [PDF]

, 2015
The conceptual breakthrough that the energy of the Na+ gradient generated by the Na+/K+ pump could be used as the driving force for another membrane transport protein has led to the functional and molecular identification of multiple secondary active transporters.
Eric Delpire, Kenneth B. Gagnon
openaire   +1 more source

Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2

Journal of Hypertension, 2017
Background: The sympathetic nervous system (SNS) regulates glucose metabolism in various organs including the kidneys. The sodium glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in renal proximal tubules and its inhibition has been shown to
V. Matthews, R. H. Elliot, C. Rudnicka, J. Hricova, L. Herat, M. Schlaich   +5 more
semanticscholar   +1 more source

Stochastic models of cotransport

Transport Theory and Statistical Physics, 1993
The author constructs discrete Boltzmann equations describing the reactions between any number of chemicals. By including a heat particle to balance the energy, a model is constructed for the chemistry of liquids that obeys the Arrhenius relation. It is proven that all isolated systems within this class of models converge to equilibrium. The models are
openaire   +2 more sources

Fournier Gangrene Associated With SodiumGlucose Cotransporter-2 Inhibitors

Annals of Internal Medicine, 2019
Fournier gangrene (FG) was named for Jean Alfred Fournier, a French dermatologist and venereologist who, in 1883, described a perineal disease of acute onset and rapid progression in previously healthy young men (1).
S. Bersoff-Matcha, C. Chamberlain, Christian Cao, C. Kortepeter, W. Chong   +4 more
semanticscholar   +1 more source

Sodium‐glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: A meta‐analysis

Diabetes/Metabolism Research Reviews, 2017
Sodium‐glucose cotransporter 2 (SGLT2) inhibitors could potentially alter calcium and phosphate homeostasis and may increase the risk of bone fracture.
Darin Ruanpeng, P. Ungprasert, Jutarat Sangtian, T. Harindhanavudhi   +3 more
semanticscholar   +1 more source

Efficacy and safety of sodium‐glucose cotransporter‐2 inhibitors versus dipeptidyl peptidase‐4 inhibitors as monotherapy or add‐on to metformin in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

Diabetes, obesity and metabolism, 2018
To compare the efficacy and safety of dipeptidyl peptidase‐4 inhibitors (DPP‐4is) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) as monotherapy or add‐on to metformin (Met) in patients with type 2 diabetes mellitus (T2DM).
Zhiying Wang, Jiahui Sun, Ruobing Han, Dongzhu Fan, Xinyi Dong, Zeng-qiang Luan, Rongwu Xiang, Mingyi Zhao, Jingyu Yang   +8 more
semanticscholar   +1 more source