Results 111 to 120 of about 1,278,247 (341)

Counsel and Defense Counsel Immunity [PDF]

open access: yesUchenye Zapiski Kazanskogo Universiteta. Seriya Gumanitarnye Nauki, 2019
The implementation of the immunities of a lawyer and defense counsel in criminal law was long overdue; in the procedural branches of law, the prohibition of their interrogation is, in fact, recognized as axiomatic, established over the centuries, perhaps, from the moment of the more or less formed legal institute.
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Forgotten intrauterine device contributing to infertility

open access: yesClinics and Practice, 2011
The aim of the study is to show that long standing forgotten intrauterine device contributes to infertility, reporting three cases presented at Central Hospital Warri, Nigeria, a government tertiary health center.
Gabriel O. Igberase
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

The Effect of Counseling on Self-Esteem and Health-promoting Behaviors in Psychiatric Patients Receiving Electroconvulsive Therapy: A Clinical Trial Study

open access: yesمراقبت پرستاری و مامایی ابن سینا, 2021
Background and Objective: Compared to the general population, patients with psychiatric disorders, especially patients receiving electroconvulsive therapy due to its nature, and lack of psychiatric nursing counseling have worse physical health and lower ...
Parisa Rostami   +2 more
doaj  

Interventions for Helping Students at Risk of Dropping Out of School [PDF]

open access: yes, 2003
Dimmitt and Hatch present a brief overview and analysis of the article, A tutorial and counseling program: Helping students at risk of dropping out of school, originally published in Professional School Counseling.
Dimmitt, Carey, Hatch, Trish
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

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