Results 191 to 200 of about 336,782 (267)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A pilot qualitative study of patient understanding and perceptions of genetic counselors and cascade testing in the context of transthyretin cardiac amyloidosis. [PDF]

J Genet Couns
Bui QM, Berninger T, Morales A, Korty L, Allen LA, Adler ED, Urey MA, Hong KN, Rabin B, Bloss C.   +9 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Time to chemotherapy and oncofertility counseling in pediatric hematology/oncology patients: a single-center retrospective review. [PDF]

Front Oncol
Mariano J, Flanagan HB, Seymour KH, SanGiacomo N, Ogbutor N, Niknafs A, Hodges B, Evans A, Baran A, Andolina JR.   +9 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The effectiveness of counseling with a motivational interview approach on health-promoting lifestyles in preventing excessive weight gain in pregnant women: Study protocol. [PDF]

J Educ Health Promot
Mohammadi S, Nasiri-Amiri F, Adib-Rad H, Faramarzi M, Nikbakht HA, Omidvar S, Ghanbarpour A.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Mapping Aural Rehabilitation Needs in a Kannada-Speaking Population: A Focus Group Study with Adults with Hearing Loss, Their Significant Others and Audiologists. [PDF]

Audiol Res
Spoorthi GN, Shastri U, Kumar K, Kalaiah MK.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Counseling in audiology practice in Saudi Arabia: perceptions, confidence, training experiences, and barriers - a cross-sectional survey. [PDF]

Front Med (Lausanne)
Alqahtani A, Almutairi B, Alkahtani R, Elbeltagy R, Alsaleh H.   +4 more
europepmc   +1 more source