A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso+5 more
wiley +1 more source
Large Language Models for Pre-mediation Counseling in Medical Disputes: A Comparative Evaluation against Human Experts. [PDF]
Kim MS, Lee JS, Bae H.
europepmc +1 more source
Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani+2 more
wiley +1 more source
Patient-reported outcomes for remote and in-person visits for genetic counseling in adult neurology. [PDF]
Paul RA+8 more
europepmc +1 more source
Hydrostatic bearings excel in high‐precision applications, but their performance hinges on a continuous external supply. This study evaluates various material combinations for sliding surfaces to mitigate damage during supply failures or misalignment and to discover the most effective materials identified for enhancing the reliability and efficiency of
Michal Michalec+6 more
wiley +1 more source
A landscape assessment of Medicaid recognition for genetic counselors. [PDF]
Reys B+6 more
europepmc +1 more source
Adherence to Treatment Regimens Among End-Stage Renal Disease Patients: A Cross-Sectional Study. [PDF]
Belhmer FS+3 more
europepmc +1 more source
Effectiveness of individualized breastfeeding counseling during the dyad's stay in rooming-in: a randomized, multicenter, open and parallel study. [PDF]
Ruiz MT+13 more
europepmc +1 more source
Associations Between Modifiable Preconception Care Indicators and Pregnancy Outcomes. [PDF]
Kamath Mulki A+7 more
europepmc +1 more source