Results 121 to 130 of about 546,250 (288)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Do EAPs work? A complex answer to a simple question. [PDF]
, 2000 The main purpose of this paper is to stimulate debate about what effectiveness means in the context of EAPs by challenging some widespread and taken-for-granted assumptions about the benefits of counselling for individual and organizational performance.
Briner, Rob B.
core
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Development of a Randomised Controlled Trial of Counselling for Depression [PDF]
, 2011 Many members of the UK counselling community feel that their profession and practice is under threat, particularly within NHS settings. This can be attributed, primarily, to the near-complete absence of recommendations for counselling in clinical ...
Cooper, Mick
core
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Discover Mental HealthBackground Expressive writing (EW) interventions are an effective, flexible, and cost-efficient option for mental health promotion, making them ideally suited for resource-limited school settings.
Janet Amos +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Effectiveness of Trust in God Training on Depression in Kahrizak Residential Center for Elderly Men
Sālmand, 2015 Objectives We aimed to examine the effect of education of trusting in God’s faith on depression in the elderly men. Methods & Materials This was a quasi-experimental study with pretest-post test design and control group.
Hadi Gholam Mohammadi +3 more
doaj
Attitudes to and perceptions of research [PDF]
, 2014 Ambivalences and uncertainties towards research are common amongst practitioners in counselling and psychotherapy. The chapter speaks directly to these concerns and suspicions and encourages the reader to reflect on their images of and fantasies about ...
Moller, Naomi, Vossler, Andreas
core