Results 121 to 130 of about 552,145 (309)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Computers in Human Behavior ReportsExecutive function (EF) is a set of higher order cognitive processes through which learning and everyday goals are realised. They comprise the fundamental building blocks of how we plan, execute, monitor and regulate tasks, and impact our cognitive ...
Susan Hindman +2 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Te Whiuwhiu o te Hau Maori Counselling Certificate Programme: Agency placements and supervision. Summary of and evaluation [PDF]
, 1995 Three major characteristics in determining a potentially successful practicum were identified. Firstly, the importance of determining early on whether an agency can expose the student to the necessary counselling experience that enables students to meet ...
Moeke-Pickering, Taima Materangatira +1 more
core +1 more source
A qualitative study into the psychological effects of acting work among Australian-based actors
Australian Journal of PsychologyObjective Acting practices can leave actors with unresolved emotions that may impact their daily life. The current study aims to describe how actors practice their craft, and how these practices are perceived in relation to their psychosocial wellbeing ...
Genevieve Brott +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Pre-service health and physical education teachers’ obesity-related nutrition knowledge and food habits [PDF]
, 2014 This study aimed to quantify the levels of nutrition knowledge of pre-service health and physical education teachers as well as their ability to provide suitable weight-based advice to overweight adolescents.
Cotton, Wayne +2 more
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