Results 131 to 140 of about 24,139,341 (352)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
POISSON MIXED MODELS WITH A BOOSTING APPROACH FOR THE ANALYSIS OF COUNT DATA
BarekengBoosting is a powerful technique for enhancing predictive accuracy by iteratively reweighting observations, and is particularly effective in high-dimensional settings and for variable selection.
Ita Wulandari +4 more
doaj +1 more source
A Comparison of Models for Count Data with an Application to Over-Dispersion Data
, 2023 Chadarat Tapan +2 more
openalex +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Comparison of the Robust Zero-Inflated and Hurdle Models with an Application to Maternal Mortality
Mathematical and Computational ApplicationsThis study evaluates the performance of count regression models in the presence of zero inflation, outliers, and overdispersion using both simulated and real-world maternal mortality dataset.
Phelo Pitsha +2 more
doaj +1 more source
Estimation of Sparse Directed Acyclic Graphs for Multivariate Counts Data
, 2016 Sung Won Han, Judy Zhong
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
AnimalsAnts are key drivers of biodiversity in both tropical and temperate forests, though the underlying mechanisms of this remain debated. In tropical lowland rainforests, ants dominate the canopy as opportunistic predators, shaping arthropod abundance and ...
Andreas Floren, Tobias Müller
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source