Results 71 to 80 of about 26,597,943 (299)

GMPR: A robust normalization method for zero-inflated count data with application to microbiome sequencing data

PeerJ, 2018
Normalization is the first critical step in microbiome sequencing data analysis used to account for variable library sizes. Current RNA-Seq based normalization methods that have been adapted for microbiome data fail to consider the unique characteristics
Li Chen, J. Reeve, Lu Zhang, Shengbing Huang, Xuefeng Wang, Jun Chen   +5 more
semanticscholar   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

iid2022: a workshop on statistical methods for event data in astronomy

Frontiers in Astronomy and Space Sciences, 2023
We review the iid2022 workshop on statistical methods for X-ray and γ-ray astronomy and high–energy astrophysics event data in astronomy, held in Guntersville, AL, on Nov. 15–18 2022.
Eric D. Feigelson, Massimiliano Bonamente   +1 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Analysis and correction of compositional bias in sparse sequencing count data

BMC Genomics, 2017
Count data derived from high-throughput deoxy-ribonucliec acid (DNA) sequencing is frequently used in quantitative molecular assays. Due to properties inherent to the sequencing process, unnormalized count data is compositional, measuring relative and ...
M. S. Kumar, E. Slud, E. Slud, Kwame Okrah, S. Hicks, S. Hannenhalli, H. C. Bravo   +6 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Policy Changes and the Demand for Lottery-Rationed Big Game Hunting Licenses

Journal of Agricultural and Resource Economics, 2000
Lotteries are commonly used to allocate big game hunting privileges. In this study, lottery demand and consumer surplus are modeled before and after policy changes designed to increase participation.
David Scrogin, Robert P. Berrens, Alok K. Bohara   +2 more
doaj   +1 more source

Daily abundance of Dall’s sheep peaks during late summer in a seasonal habitat of high‐management interest

Ecosphere, 2022
Informing conservation and management decisions for habitats frequented by species of high management interest often face the challenge of limited resources for conducting wildlife surveys.
Cody E. Deane, Barrett A. Flynn, Darren L. Bruning, Greg A. Breed, Kim A. Jochum   +4 more
doaj   +1 more source

Efficiently inferring the demographic history of many populations with allele count data

bioRxiv, 2018
The sample frequency spectrum (SFS), or histogram of allele counts, is an important summary statistic in evolutionary biology, and is often used to infer the history of population size changes, migrations, and other demographic events affecting a set of ...
J. Kamm, Jonathan Terhorst, R. Durbin, Yun S. Song   +3 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source