Results 201 to 210 of about 40,178 (259)
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Oncolytic virus purification with periodic counter‐current chromatography
Biotechnology and Bioengineering, 2021AbstractVirus‐based biologicals are one of the most promising biopharmaceuticals of the 21st century medicine and play a significant role in the development of innovative therapeutic, prophylactic, and clinical applications. Oncolytic virus manufacturing scale can range from 5 L in research and development up to 50 L for clinical studies and reach ...
João P. Mendes +6 more
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Evaluation of dual flow counter-current chromatography and intermittent counter-current extraction
Journal of Chromatography A, 2011The aim of this research is to compare two continuous extraction technologies, intermittent counter-current extraction (ICcE) and dual flow counter-current chromatography (DFCCC), in terms of loading and throughput using the GUESSmix, and show the advantages and disadvantages of the two methods.
Svetlana, Ignatova +3 more
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Counter-Current Chromatography
1986Counter-current chromatography is characterised by the absence of a solid support, the factor which provides the most important advantage of this separation technique. Solutes are readily retained by solid supports and these adsorption effects are often manifested by elution curves which show tailing of the substances under consideration.
Kurt Hostettmann +2 more
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Separation of antibiotics by counter-current chromatography
Journal of Chromatography A, 1998This paper reviews recent applications of counter-current chromatography (CCC) to the separation of antibiotics. It also covers the recent development of CCC instruments and the optimization of the two-phase solvent system. The CCC technique offers a high resolving power when the proper solvent system is carefully selected and becomes a powerful tool ...
H, Oka, K, Harada, Y, Ito, Y, Ito
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Separation of acetins by counter‐current chromatography
Journal of Separation Science, 2011AbstractIn this work we report the purification of a crude acetin mixture into mono‐, di‐ and triacetin by countercurrent chromatography. The process was initially tested on a small, semi‐preparative scale (0.5 g) to determine its efficiency. The process was then scaled up to accommodate 2.5 g of crude reaction products containing a mixture of the ...
Bruno Amaral, Meireles +3 more
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Modeling counter-current chromatography with non-ideal injection
Journal of Chromatography A, 2020In general counter-current chromatography systems, there are several off-column fittings between injector and column inlet, such as bends, valves, connecting tubes and joints. Due to these off-column fittings, the sample will diffuse in the mobile phase and form an irregular distribution when it flows from the injector to the column inlet.
Haijun, Chen +7 more
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Recent trends in counter-current chromatography
TrAC Trends in Analytical Chemistry, 2012Abstract Counter-current chromatography (CCC) has been widely used as a preparative chromatography technique since Ito first developed it in the late 1960s. This technique uses a support-free liquid stationary phase, which is retained by gravity or centrifugal force. The analytes can access the whole stationary phase, leading to effective separation.
Ruilin Hu, Yuanjiang Pan
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Controlled-cycle counter-current chromatography
Journal of Chromatography A, 2008The application of the technique of controlled-cycle operation to counter-current chromatography is suggested and evaluated. The operating cycle as applied to a chromatographic column would consist of two individually timed periods: (1) Flow period: a specified volume of mobile phase is fed into one end of the column, conveyed through it, and ...
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Recent advances in counter-current chromatography
Journal of Chromatography A, 1991During the past several years, counter-current chromatography (CCC) technology has been advanced to cover a broad spectrum of applications, from large-scale preparative to analytical-scale separations. These advances include liquid-liquid dual CCC, foam CCC and partition of macromolecules with aqueous-aqueous polymer phase systems.
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Recent Development in Counter-current Chromatography
Chinese Journal of Analytical Chemistry, 2016Abstract Counter-current chromatography (CCC) is a quick preparative separation technique with immiscible liquid-liquid solvent systems. This paper reviews recent research progress in the instruments improvement of CCC and screening of solvent systems. Moreover, some applications and prospective about chiral resolution by CCC are discussed.
Da-Tong WU, Yuan-Jiang PAN
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