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Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

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Recent trends in counter-current chromatography

TrAC Trends in Analytical Chemistry, 2012
Abstract Counter-current chromatography (CCC) has been widely used as a preparative chromatography technique since Ito first developed it in the late 1960s. This technique uses a support-free liquid stationary phase, which is retained by gravity or centrifugal force. The analytes can access the whole stationary phase, leading to effective separation.
Ruilin Hu, Yuanjiang Pan
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Chiral separation by counter-current chromatography

TrAC Trends in Analytical Chemistry, 2015
Counter-current chromatography (CCC) is a new, efficient, productive chromatographic technique based on continuous liquid-liquid partition. Recently, it attracted more attention in chiral separation due to its high load capacity, cheap liquid stationary phase and low solvent consumption, when compared to traditional chiral separation techniques.
Xin-Yi Huang, Duo-Long Di
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Two-dimensional counter-current chromatography: 1st Traditional counter-current chromatography, 2nd acid–base elution counter-current chromatography

Journal of Chromatography A, 2011
An on-line column-switching counter-current chromatography (CCC) with solid-phase trapping interphase is presented in this paper. The large volume injection is avoided using solid-phase trapping interphase. Thereby, totally different chemical composition biphasic solvent system can be utilized to enhance system orthogonality. In the present work, a 140
Ruilin, Hu, Xiaojing, Dai, Xia, Xu, Cuirong, Sun, Yuanjiang, Pan   +4 more
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Universal counter-current chromatography modelling based on counter-current distribution

Journal of Chromatography A, 2009
There is clearly a need for a model which is versatile enough to take into account the numerous operating modes and pump out procedures that can be used with counter-current chromatography (CCC). This paper will describe a universal model for counter-current chromatography based on counter-current distribution.
Joost, de Folter, Ian A, Sutherland
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Counter-current chromatography.

Journal of chromatography, 1991
Abstract The simplicity of counter-current chromatography (CCC) is sometimes overshadowed by a complex description of its mechanical and chromatographic attributes. The universal features of chromatographic theory relevant to CCC are summarized here, using a partition coefficient elution scale to present th chromatogram in a general, readily ...
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Counter-current chromatography of black tea infusions

Journal of Chromatography A, 1990
Counter-current chromatography using a multilayer coil planet centrifuge, with solvent system ethyl acetate-butanol-water, permits the separation of black tea infusions into fractions which include pure SII and a mixture of SI and SIa thearubigins. Good resolution of several components of the infusion may be achieved in elution times of 1 to 2 h.
B L, Wedzicha, M F, Lo, T J, Donovan
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Oncolytic virus purification with periodic counter‐current chromatography

Biotechnology and Bioengineering, 2021
AbstractVirus‐based biologicals are one of the most promising biopharmaceuticals of the 21st century medicine and play a significant role in the development of innovative therapeutic, prophylactic, and clinical applications. Oncolytic virus manufacturing scale can range from 5 L in research and development up to 50 L for clinical studies and reach ...
João P. Mendes, Ricardo J. S. Silva, Mikael Berg, Linda Mathiasson, Cristina Peixoto, Paula M. Alves, Manuel J. T. Carrondo   +6 more
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Evaluation of dual flow counter-current chromatography and intermittent counter-current extraction

Journal of Chromatography A, 2011
The aim of this research is to compare two continuous extraction technologies, intermittent counter-current extraction (ICcE) and dual flow counter-current chromatography (DFCCC), in terms of loading and throughput using the GUESSmix, and show the advantages and disadvantages of the two methods.
Svetlana, Ignatova, Peter, Hewitson, Ben, Mathews, Ian, Sutherland   +3 more
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Counter-Current Chromatography

1986
Counter-current chromatography is characterised by the absence of a solid support, the factor which provides the most important advantage of this separation technique. Solutes are readily retained by solid supports and these adsorption effects are often manifested by elution curves which show tailing of the substances under consideration.
Kurt Hostettmann, Maryse Hostettmann, Andrew Marston   +2 more
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