Results 61 to 70 of about 31,128 (288)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

XPS and XMCD study of Fe3O4/GaAs interface [PDF]

, 2005
Ultrathin Fe oxide films of various thicknesses prepared by post-growth oxidation on GaAs(100) surface have been investigated with X-ray photoelectron spectroscopy (NPS), X-ray absorption spectroscopy (XAS), and X-ray magnetic circular dichroism (XMCD ...
Ahmad, E, Claydon, J S, Lu, Y X, Thompson, S M, van der Laan, G, Wilson, Karen, Xu, Y B   +6 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Work-Unit Absenteeism: Effects of Satisfaction, Commitment, Labor Market Conditions, and Time [PDF]

, 2008
Prior research is limited in explaining absenteeism at the unit level and over time. We developed and tested a model of unit-level absenteeism using five waves of data collected over six years from 115 work units in a large state agency.
Agostinelli G., Bacharach S., Bamberger P., Becker T. E., Blau G., Blau G. J., Blau G. J., Bliese P. D., Bliese P. D., Bliese P. D., Brooke P. P., Brown N., Brown R. D., Brown S. P., Cappelli P., Chartered Institute of Personnel and Development., Chen G., Cialdini R. B., Cohen J., Cropanzano R., Dalton D. R., Day D. V., Diez-Roux A. V., Dineen B. R., Eisenberger R., Fichman M., Gellatly I. R., George J. M., Hackett R. D., Hammer T. H., Harrison D. A., Harrison D. A., Harrison D. A., Harrison D. A., Harvey J., Hulin C. L., Ilgen D. R., Iverson R. D., John P. Hausknecht, Johns G., Larson E. W., Lawler E. E., Lee T. W., Leigh J. P., Leonard C., Markham S. E., Markham S. E., Markham S. E., Markham S. E., Markham S. E., Martocchio J. J., Maruyama M., Mason C. M., Mathieu J. E., Mathieu J. E., Mathieu J. E., Meyer J. P., Meyer J. P., Meyer J. P., Monge P. R., Muchinsky P. M., Nathan J. Hiller, Nicholson N., Ostroff C., Ployhart R. E., Raudenbush S. W., Rentsch J. R., Rentsch J. R., Robert J. Vance, Rosse J. G., Ryan A. M., Salancik G. R., SAS Institute., Schneider B., Singer J. D., Steel R. P., Steel R. P., Steers R. M., Steers R. M., Sturman M. C., Tabachnick B. G., Terborg J. R., Thoreson C. J., Trevor C. O., Unscheduled absences rising at U.S. workplaces., Van Knippenberg D., Warr P., Xie J. L., Zaccaro S. J., Zaccaro S. J.   +89 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

The Mechanism of Formation of Extremist Attitudes in Minors

Теория и практика судебной экспертизы, 2018
In this paper key trends in the development of extremist and near-extremist youth subcultures are outlined, and characteristic features of criminal and near-criminal youth organizations are described.
E. V. Vaske, O. I. Goryunova
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

PROBLEMS OF EFFICIENT COORDINATION OF ANTI-CORRUPTION ACTIVITY

Russian Journal of Economics and Law, 2014
Objective: identification of problems of more efficient coordination of anti-corruption struggle and their solutions. Methods: abstract-logical method, system analysis, sociological, etymological, historical, legal and other general and private ...
A. A. Maksurov
doaj  

The main directions of counteraction to the “russian world” in Ukraine: the tasks of decolonization

Філософія освіти
Despite the fact that there is now a general public agreement in Ukraine regarding the need to oppose the “russian world”, there are quite diverse and sometimes contradictory proposals among Ukrainian citizens regarding the ways to implement such an ...
Михайло Бойченко
doaj   +1 more source