Results 41 to 50 of about 46,376 (256)
Drug Delivery, 2022 Successful gene therapy for brain tumors are often limited by two important factors, the existence of blood brain barrier (BBB) and inefficient transfection of brain tumor cells.
Ziyao Kang +9 more
doaj +1 more source
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication
Advanced Science, EarlyView.NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan +7 more
wiley +1 more source
Scientific Reports, 2022 Due to concealed initial symptoms, many diabetic patients are not diagnosed in time, which delays treatment. Machine learning methods have been applied to increase the diagnosis rate, but most of them are black boxes lacking interpretability.
Jingwei Hao, Senlin Luo, Limin Pan
doaj +1 more source
Advanced Science, EarlyView.An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou +4 more
wiley +1 more source
BMC Bioinformatics, 2021 Background Querying drug-induced gene expression profiles with machine learning method is an effective way for revealing drug mechanism of actions (MOAs), which is strongly supported by the growth of large scale and high-throughput gene expression ...
Shengqiao Gao +7 more
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Advanced Science, EarlyView.Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun +6 more
wiley +1 more source
Terahertz Channel Modeling, Estimation and Localization in RIS‐Assisted Systems
Advanced Electronic Materials, EarlyView.Reconfigurable intelligent surfaces have become a recent intensive research focus. Based on practical applications, channel strategies for RIS‐assisted terahertz wireless communication systems are categorized into three different types: channel modeling, channel estimation, and channel localization.
Hongjing Wang +9 more
wiley +1 more source
Research on the NOX concentration inversion based on the W-V-A wavelength selection method
AIP Advances, 2019 In view of the shortcomings of traditional wavelength selection algorithm in the processing of mixed NOX spectral data, combined with the absorption characteristics of engine exhaust component NO&NO2, the W-V-A (WPLS-VIP-ACO) spectral wavelength ...
Kai Zhang +4 more
doaj +1 more source
Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary
Gels, 2022 In recent years, hydrogel-based research in biomedical engineering has attracted more attention. Cellulose-based hydrogels have become a research hotspot in the field of functional materials because of their outstanding characteristics such as excellent ...
Pengfei Zou +7 more
doaj +1 more source