Results 61 to 70 of about 226,084 (298)
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Rotatory Thermosolutal Convection in a Couple-Stress Fluid
Zeitschrift für Naturforschung A, 2009 Abstract The thermosolutal instability of couple-stress fluid in the presence of uniform vertical rotation is considered. Following the linearized stability theory and normal mode analysis, the dispersion is obtained. For the case of stationary convection, the stable solute gradient and rotation have stabilizing effects on the system ...
Pardeep Kumar, Mahinder Singh
openaire +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Pulsating Fronts in a 2D Reactive Boussinesq System [PDF]
, 2013 We consider a reactive Boussinesq system with no stress boundary conditions in a periodic domain which is unbounded in one direction. Specifically, we couple the reaction-advection-diffusion equation for the temperature, $T$, and the linearized Navier ...
Henderson, Christopher
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Flow of Two Immiscible Couple Stress Fluids between Two Permeable Beds
Journal of Applied Fluid Mechanics, 2016 The paper deals with the flow of two immiscible couple stress fluids between two homogeneous permeable beds. The flow is considered in two zones: zone I and II contain free flow of two immiscible couple stress fluids between two permeable porous beds ...
Dr. Srinivas Jangili +1 more
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A higher order control volume based finite element method to prodict the deformation of heterogeneous materials [PDF]
, 2013 Materials with obvious internal structure can exhibit behaviour, under loading, that cannot be described by classical elasticity. It is therefore important to develop computational tools incorporating appropriate constitutive theories that can capture ...
A.J. Beveridge +27 more
core +1 more source