Results 61 to 70 of about 19,721 (254)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Migration of two rigid spheres translating within an infinite couple stress fluid under the impact of magnetic field

Open Physics
In this study, we examine the movement of two hard spheres aligned in a straight line within an incompressible couple stress fluid under the impact of the magnetic field.
El-Sapa Shreen, Alotaibi Munirah Aali
doaj   +1 more source

Nonlinear Dynamical Analysis for a Plain Bearing

Advances in Mechanical Engineering, 2014
This paper investigates the nonlinear dynamic behavior for a plain classic bearing (fluid bearing) lubricated by a non-Newtonian fluid of a turbo machine rotating with high speed; this type of fluid contains additives viscosity (couple-stress fluid film).
Ali Belhamra, Ouafa Meramria, Khalil Kahine, Fadi Haj Chehade   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Analysis of the Lubrication Performance of Bearing with Non-Newtonian Magnetic Fluids with Considering Stress Couple Effect

Jixie chuandong, 2017
Based on the Reynolds equation considering the stress couple and magnetic field,the numerical analysis of the non-Newtonian magnetic fluid lubricated bearing is carried out.
Chen Chao, Zhang Hong
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Magneto-rotatory compressible couple-stress fluid heated from below in porous medium

Studia Geotechnica et Mechanica, 2016
The study is aimed at analysing thermal convection in a compressible couple stress fluid in a porous medium in the presence of rotation and magnetic field.
Mehta Chander Bhan
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Effects of Couple Stress on the Growth Rate of Rayleigh- Taylor Instability at the Interface in a Finite Thickness Couple Stress Fluid

Journal of Applied Fluid Mechanics, 2010
In this paper the effects of couple stress fluid on the control of Rayleigh-Taylor instability at the interface between a dense fluid accelerated by a lighter fluid is studied. A simple theory, based on fully developed approximations, is used to derive
N. Rudraiah, G. Chandrashekara
doaj