Results 61 to 70 of about 4,063,868 (240)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Influence of wall couple stress in MHD flow of a micropolar fluid in a porous medium with energy and concentration transfer

Results in Physics, 2018
The intention here is to investigate the effects of wall couple stress with energy and concentration transfer in magnetohydrodynamic (MHD) flow of a micropolar fluid embedded in a porous medium.
Asma Khalid, Ilyas Khan, Arshad Khan, Sharidan Shafie   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Natural convection flow of heat generating hydromagnetic couple stress fluid with time periodic boundary conditions

Alexandria Engineering Journal, 2018
In this paper, analysis has been conducted to investigate the effects of couple stresses and internal heat generation on the magnetohydrodynamic (MHD) natural convection channel flow with steady-periodic heat input.
Samuel O. Adesanya, C.R. Makhalemele, L. Rundora   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Migration of two rigid spheres translating within an infinite couple stress fluid under the impact of magnetic field

Open Physics
In this study, we examine the movement of two hard spheres aligned in a straight line within an incompressible couple stress fluid under the impact of the magnetic field.
El-Sapa Shreen, Alotaibi Munirah Aali
doaj   +1 more source

Nonlinear Dynamical Analysis for a Plain Bearing

Advances in Mechanical Engineering, 2014
This paper investigates the nonlinear dynamic behavior for a plain classic bearing (fluid bearing) lubricated by a non-Newtonian fluid of a turbo machine rotating with high speed; this type of fluid contains additives viscosity (couple-stress fluid film).
Ali Belhamra, Ouafa Meramria, Khalil Kahine, Fadi Haj Chehade   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

On the characterisation of polar fibrous composites when fibres resist bending – Part III: The spherical part of the couple-stress [PDF]

, 2020
Part II (Soldatos 2018b) identified some theoretical disagreement between the generally anisotropic polar linear elasticity of Mindlin and Tiersten (1962) and its counterpart developed in (Spencer and Soldatos, 2007; Soldatos, 2014) for fibrous ...
Soldatos, K. P.
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source