FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Reflexive audiencing practices for couple relationships-in-action [PDF]
, 2012 This doctoral study offers couples opportunities to be audiences to their own lives as a couple. It does this on the premise that a reflexive, recursive, process of acting and reviewing and acting enhances relationship possibilities.
Talbot, Wendy
core
Comparing the Effectiveness of Cognitive-Behavioral Couple Therapy and Gottman Couple Therapy on Marital Satisfaction and Problem Solving Styles in Couples Referring to Counseling Centers in Lamard and Mohr City [PDF]
Iranian Evolutionary Educational Psychology Journal, 2023 Objective: The present study aimed to compare the effectiveness of cognitive behavioral couple therapy and Gottman couple therapy on marital satisfaction and problem solving styles of couples.
S. Abdulmajid Mosavi +4 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Web-Based Couple Interventions: Do They Have a Future?
, 2013 To examine the current and potential future impact of formal and informal resources to enhance romantic relationships, 1,160 individuals were surveyed. When asked about resources previously used, participants reported that numerous forms of relationship ...
Georgia, Emily J, Doss, Brian D
core +1 more source
The Comparison Effectiveness Wisdom-Focused Couple Therapy with Emotional-Focused Couple Therapy on Sense of Coherence in Couples with Marital Conflicts [PDF]
روانشناسی بالینی و شخصیتIntroduction: This research aims to compare the effectiveness of wisdom-focused couple therapy with emotion-focused couple therapy in enhancing the sense of coherence among couples experiencing marital conflicts.Method: This study employed a semi ...
Nazanin Khoshbakht +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source