Results 121 to 130 of about 909,675 (305)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Tomorrow's Metamaterials: Manipulation of Electromagnetic Waves in Space, Time and Spacetime
, 2016 Metamaterials represent one of the most vibrant fields of modern science and technology. They are generally dispersive structures in the direct and reciprocal space and time domains.
Caloz, Christophe
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A microstrip bandpass filter using coupled lines loaded by open stubs
Scientific ReportsA compact simple structure bandpass filter based on terminated three coupled line structures with high selectivity is introduced through odd and even-mode analysis.
Sadegh Heydari Kahkesh, Akram Sheikhi
doaj +1 more source
Novel technique of phase velocity equalization for microstrip coupled-line phase shifters [PDF]
, 2000 By properly selecting the characteristic impedance and electrical length of the linking line between the coupled lines, phase velocity compensation for microstrip coupled-line phase shifters can be achieved.
Leong, Y. C., Weinreb, S.
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A New Class of Wideband Quadrature Coupled-Line Forward Couplers
IEEE Journal of MicrowavesThis paper presents a new class of wideband quadrature coupled-line forward couplers making use of the unequal phase velocities of even- and odd-mode of coupled-lines in inhomogeneous media.
Henning Mextorf, Winfried Schernus
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source