Results 41 to 50 of about 53,002 (201)

On the C-class functions of fixed point and best proximity point results for generalised cyclic-coupled mappings

Cogent Mathematics, 2016
Existence of fixed point for C-class functions was first proved by Ansari in 2014. Then, many authors gave interesting results using C-class functions. In this paper, we prove the existence of strong coupled proximity point for generalised cyclic-coupled proximal maps. Our result generalises the results of Kadwin and Marudai.
Arslan Hojat Ansari, Geno Kadwin Jacob, Muthiah Marudai, Poom Kumam   +3 more
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Optimum solution of ( k , ℷ ) $(k,\gimel )$ -Hilfer FDEs by A $\mathcal{A}$ -condensing operators and the incorporated measure of noncompactness

Journal of Inequalities and Applications
The notion of A $\mathcal{A}$ -condensing operators via the measure of noncompactness is proposed, which retains the existing classes of condensing operators.
Gurpreet Kaur Khokhar, Deepesh Kumar Patel, Pradip Ramesh Patle, Mohammad Esmael Samei   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Application to fixed point theory of -Geraghty Pata proximal contractions

Fixed Point Theory and Algorithms for Sciences and Engineering
In this paper, we introduce the concepts of -Geraghty Pata proximal contractions and their weak ϕ-variants, which generalize and unify several well-known contraction conditions in fixed point theory.
Khairul Habib Alam, Yumnam Rohen, Amer Hassan Albargi, Aftab Hussain   +3 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Properties of the frustrated spin 1/2 kagome material Cu_{3}(HOTP)_{2}

Physical Review Research
The metal-organic-framework compound Cu_{3}(HOTP)_{2}, also known as Cu_{3}(HHTP)_{2}, is a small-gap semiconductor containing a kagome lattice of antiferromagnetically coupled S=1/2Cu^{II} spins with intralayer nearest-neighbor exchange coupling J∼ 2 K.
F. L. Pratt, D. López-Alcalá, V. Garcia-Lopez, M. Clemente-León, J. J. Baldoví, E. Coronado   +5 more
doaj   +1 more source