Results 201 to 210 of about 25,807 (263)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Numerical investigation of the effects of excavation on piled embankments under static loading conditions. [PDF]

Sci Rep
Soomro MA, Xu T, Romanov S, Gulvanskii V, Kaplun D, Bukhari MH.   +5 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice. [PDF]

Elife
Varani AP, Mailhes-Hamon C, Sala RW, Sarraudy M, Fouda S, Frontera JL, Léna C, Popa D.   +7 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Poor platelet engraftment combined with persistent pulmonary infection after haploidentical allogeneic hematopoietic stem cell transplantation: a case report. [PDF]

Front Med (Lausanne)
He Y, Xiong Y, Zhang J, Gan X, Fan F, Yi H.   +5 more
europepmc   +1 more source

Palo Santo (Bursera graveolens) essential oil nanoemulsion: toxicological, antinociceptive and antimicrobial potential against bovine mastitis-associated strains. [PDF]

Antonie Van Leeuwenhoek
Figueiredo AM, Dos Reis SVV, Rodrigues AA, Silva JL, Colombo IM, Leite LMDB, Neder JVB, Honório ICG, Almeida-Junior S.   +8 more
europepmc   +1 more source

Case report: life-threatening endocarditis in an adult with repaired congenital heart disease lost to follow-up. [PDF]

Eur Heart J Case Rep
Wilson RM, Arif Z, Sturridge L.
europepmc   +1 more source