Results 81 to 90 of about 187,917 (279)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
EU fiscal consolidation after the financial crisis. Lessons from past experiences [PDF]
Summary for non-specialistsThe global financial crisis has led to a sharp deterioration of EU countries' public finances. Views are split regarding the most appropriate consolidation strategy to follow, in particular considering: the timing of fiscal ...
Lucio Pench +2 more
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Underground SpaceThis paper presents a solution for the time-dependent behaviors of energy piles embedded in transversely isotropic soils, which considers the mechanical and thermal consolidation.
Yongzhi Zhao, Zhenming Shi, Zhiyong Ai
doaj +1 more source
Effective and neutral stresses in soils using boundary element methods [PDF]
, 1983 The evaluation of neutral pressures in soil mechanics problems is a fundamental step to evaluate deformations in soils. In this paper, we present some results obtained by using the boundary element method for plane problems, describing the undrained ...
Alarcón Álvarez, Enrique +2 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Land Subsidence Prediction by Back Calculation Method and its Effects on Sewage Network [PDF]
آب و فاضلاب, 2009 Groundwater overdraft is one of the main reasons of land subsidence. Differential subsidence leads to earth fissures and damages to structures, roads, railroads, pipelines, irrigation canals, and sewage networks.
Mohammad Mohsen Toufigh +1 more
doaj
Strengthening the annual financial statements of the banks [PDF]
Strengthening of the annual financial statements of companies that are in some cases explicitly regulated is a legal obligation stemming on the part of international practice and on the other side of prudential requirements and supervision.
Troaca, Mihaela-Elvira, Troaca, Victor
core +1 more source
Artequakt: Generating tailored biographies from automatically annotated fragments from the web [PDF]
, 2002 The Artequakt project seeks to automatically generate narrativebiographies of artists from knowledge that has been extracted from the Web and maintained in a knowledge base.
Alani, Harith +6 more
core