Results 171 to 180 of about 682,008 (293)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Experimental and Numerical Study of Coupled Metronomes on a Floating Platform. [PDF]

Entropy (Basel)
Wu X, Zheng C, Lei Z, Qian Y, Di Z, Cui X.   +5 more
europepmc   +1 more source

Applications and common coupled fixed point results in ordered partial metric spaces [PDF]

, 2017
K. P. R. Rao, G. N. V. Kishore, Kenan Taş, S Satyanaraya, Daripally Ram Prasad   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Quantum Phase Transitions in Graphene Coupled to a Twisted WSe₂ Moiré Ferroelectricity. [PDF]

Adv Mater
Singh B, Hassan Y, Ali N, Durairaj S, Jang J, Ngo TD, Saini J, Abbas MS, Watanabe K, Taniguchi T, Choi MS, Ghosh S, Kim T, Jeong HM, Lee S, Yoo WJ, Srivastava PK, Lee C.   +17 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Convex Hartree-Fock theory for modeling ground state conical intersections. [PDF]

Commun Chem
Rossi F, Koch H.
europepmc   +1 more source

COMMON COUPLED FIXED POINT THEOREMS FOR TWO HYBRID PAIRS OF MAPPINGS SATISFYING AN IMPLICIT RELATION

, 2019
B. Deshpande, Amrish Handa
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Experimental evaluation of the effect of openings on the structural performance of diagonally reinforced coupling beams. [PDF]

Sci Rep
Elghool A, Elshafey N, Ramadan OMO, Elbayomy MS.   +3 more
europepmc   +1 more source