Results 111 to 120 of about 1,148,154 (395)

Dynamic energy flow analysis of electricity-heating based integrated energy system

Energy Reports, 2023
With the development of integrated energy system, energy flow analysis of coupling energy network has attracted much attention. In this study, based on the unified energy path theory, energy flow analysis of electricity-heating coupled energy system is ...
Qiong Wu, Min Chen, Hongbo Ren, Shanshan Shi, Yun Su, Jiawen Lu   +5 more
doaj  

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Formulation of a method for predicting coupled convective and radiative heat transfer about a blunt body [PDF]

Method for predicting coupled convective and radiative heat transfer about blunt ...
Engel, C. D., Spradley, L. W.
core   +1 more source

Magnetohydrodynamic Analysis and Fast Calculation for Fractional Maxwell Fluid with Adjusted Dynamic Viscosity

Magnetochemistry
From the perspective of magnetohydrodynamics (MHD), the heat transfer properties of Maxwell fluids under MHD conditions with modified dynamic viscosity present complex challenges in numerical simulations.
Yi Liu, Mochen Jiang
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Numerical study of evaporation–condensation heat transfer in finned double pipe heat exchangers

Case Studies in Thermal Engineering
Double pipe heat exchangers (DPHEs) are widely used in industrial fields, such as refrigeration, heat pumps, and chemical industry, owing to their efficient coupled heat transfer characteristics of evaporation and condensation. In this study, the effects
Junrong Yang, Tianming Zhong, Xin Yan, Haokun Li, Zhilin He, Haoxian Bai, Shiwen Fang   +6 more
doaj  

Coupling methods for heat transfer and heat flow: Operator splitting and the parareal algorithm

Journal of Mathematical Analysis and Applications, 2012
AbstractWe propose an operator splitting method for coupling heat transfer and heat flow equations. This work is motivated by the need to couple independent industrial heat transfer solvers (e.g., the Aura-Fluid software package) and heat flow solvers (e.g., Openfoam).
Stefan Güttel, Jürgen Geiser
openaire   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source