Results 91 to 100 of about 1,058,541 (295)
Modeling economic systems as locally-constructive sequential games [PDF]
, 2017 Real-world economies are open-ended dynamic systems consisting of heterogeneous interacting participants. Human participants are decision-makers who strategically take into account the past actions and potential future actions of other participants.
Tesfatsion, Leigh, Tesfatsion, Leigh
core +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Energy efficient homes for rodent control across cityscapes
Environmental Research LettersCities spend millions of dollars on rodent mitigation to reduce public health risks. Despite these efforts, infestations remain high and distressing. Rodents thrive in the built environment in part due to reduced natural predators and their exploitation ...
Gabriel I Gadsden +2 more
doaj +1 more source
Even at the uttermost ends of the Earth: how seabirds telecouple the Beagle Channel with regional and global processes that affect environmental conservation and socio-ecological sustainability [PDF]
, 2017 Human-wildlife dynamics exhibit novel characteristics in the Anthropocene, given the unprecedented degree of globalization that has increased the linkages between habitats and people across space and time. This is largely caused by transnational mobility
Anderson, Christopher Brian +3 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
β-Barrel scaffolds for the grafting of extracellular loops from G-protein-coupled receptors [PDF]
, 2017 Owing to the difficulties in production and purification of G-protein-coupled receptors (GPCRs), relatively little structural information is available about this class of receptors.
Kleinschmidt, Jörg H. +3 more
core +1 more source
Ecosystem Health and Sustainability, 2017 Introduction: As challenges to biodiversity mount, land-use policies have been implemented to balance human needs and the integrity of ecological systems.
Rebecca L. Lewison, Li An, Xiaodong Chen
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Global aging: emerging challenges [PDF]
, 2009 This repository item contains a single issue of The Pardee Papers, a series papers that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.
Crampton, Alexandra
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source