Results 91 to 100 of about 267,842 (253)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Managing coupled human and natural systems (CHANS) : the case of water [PDF]

, 2022
Many sustainability challenges of the 21st century are the result of poor management of coupled human and natural systems (CHANS). Limited understanding of the mechanisms that give rise to complex dynamics in CHANS has contributed to overexploitation and degradation of water and other natural resources around the globe, leading to unintended ...
openaire  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Coupled Human and Natural Systems [PDF]

BioScience, 2015
openaire   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A High‐Performance Coupled Human And Natural Systems (CHANS) Model for Flood Risk Assessment and Reduction

Water Resources Research
In recent years, flood risk in urban areas has been rapidly increasing due to unsustainable urban development, changes of hydrological processes and frequent occurrence of extreme weather events.
Haoyang Qin, Qiuhua Liang, Huili Chen, Varuna DeSilva   +3 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Hunting motivations, behaviour and forest access: Characterising wildlife hunting practices in a multi‐ethnic, forested landscape of Brunei Darussalam, Southeast Asia

People and Nature
Unsustainable hunting practices can alter population dynamics, driving biodiversity declines, which leads to ‘empty forests’. Understanding hunting behaviour, including motivations for hunting and relationships with market drivers, and access to hunting ...
Natasha L. M. Mannion, Rachel Gaulton, Maria Erica Jamil, Marion Pfeifer, Johan Willem Ferry Slik, Stephen G. Willis, F. Merlin Franco   +6 more
doaj   +1 more source

Layering for governance: Ecosystem service supply–demand trade-offs and social-ecological system network topologies from a cluster perspective

Ecological Indicators
A key challenge in ensuring the coordinated development of ecological conservation and economic growth is to gain a solid understanding of the interactions between supply–demand of ecosystem services (ES). However, empirical research on spatial imbalance
Linsheng Wen, Yanhua Yu, Manuel Esperon-Rodriguez, Yun Peng, Sunbowen Zhang, Aifang Weng, Baoyin Li, Yuying Lin   +7 more
doaj   +1 more source