Results 131 to 140 of about 1,058,541 (295)

Coupled Human and Natural Systems: A Novel Framework for Complexity Management

Sustainability
Coupled human and natural systems (CHANS) represent dialectic interaction between human and nature subsystems. This dynamic interaction involves a prominent level of complexity stemming from the uncertain interrelation between the systems and the incorporated subsystems.
Dhanushki Perera, Ziyad Abunada, Ahmed AlQabany   +2 more
openaire   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Revisiting the Gaia hypothesis: Maximum Entropy, Kauffman's 'Fourth Law' and physiosemeiosis [PDF]

Recently, Kleidon suggested a restatement of the Gaia hypothesis based on Maximum Entropy approaches to the Earth system. Refuting conceptions of Gaia as a homeostatic system, Gaia is seen as a non-equilibrium thermodynamic system which continuously ...
Herrmann-Pillath, Carsten
core  

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Coupled Human and Natural Systems [PDF]

BioScience, 2015
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Dynamics of coupled human and natural systems in epidemiology and ecology

, 2017
Many natural systems exist in a state of two-way coupling with human systems, where changes in the human system create changes in the natural system, which in turn create changes in the human system once again. The study of dynamics of such coupled human-and-natural systems is a growing area of research. For instance, in the case of influenza antiviral
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Coupling natural-social models can better quantify the interactions in achieving carbon neutrality in China

Environmental Research Letters
Human activities have greatly altered Earth’s radiative balance, necessitating assessments that couple natural and social systems to address the resulting impacts and interactions. However, traditional Earth System Models (ESMs) and integrated assessment
Tianpeng Wang, Yixiong Lu, Fei Teng, Xiliang Zhang, Xiaoye Zhang, Min Wei, Tongwen Wu, Deying Wang, Jing Sun, Junting Zhong   +9 more
doaj   +1 more source

Coupled natural and human systems: a landscape ecology perspective [PDF]

Landscape Ecology, 2014
Jiquan Chen, Yongqiang Liu
openaire   +1 more source