Results 41 to 50 of about 1,305,655 (270)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A Coupled-Inductor Interleaved LLC Resonant Converter for Wide Operation Range

Energies, 2022
In this paper, a coupled-inductor interleaved LLC resonant converter (CI-ILLC) was proposed, which can achieve extensive operation range applications by multiplexing inductors and switches.
Qianfan Zhou, Yang Liu, Zongjian Li, Zhixing He   +3 more
doaj   +1 more source

An Enhanced-Boost Coupled-Inductor Impedance Network Inverter Without Limitation of Inductor Parameters

, 2022
In this article, an enhanced-boost coupled-inductor impedance network inverter (EBCL-INI) is presented. Being better than other impedance-source inverters, the proposed EBCL-INI can avoid the dc-link voltage drop caused by the discontinuous inductor ...
Ji, Yuliang, Geng, Lina, Liu, Hongchen, Li, Fei, Wheeler, Pat, Yuliang Ji, Fei Li, Lina Geng, Pat Wheeler, Hongchen Liu   +9 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Using a coupled inductor controlled by fuzzy logic to improve the efficiency of a Buck converter in a PV system

E3S Web of Conferences, 2017
Photovoltaic generators (PVG) produce a variable power according to the solar radiation (G) and temperature (T). This variation affects the sizing of the components of DC / DC converters, powered by such PVG, and make it difficult. The effects may differ
Abouchabana Nabil, Haddadi Mourad, Rabhi Abdelhamid, El Hajjaji Ahmed   +3 more
doaj   +1 more source

Dimensioning and Modeling of a Circular Inductor Integrated in a Boost Converter [PDF]

Журнал нано- та електронної фізики, 2016
This paper presents the dimensioning and modeling of a circular inductor integrated in a Boost micro converter. At first, we define the characteristics of the Boost micro converter, which is the starting point for the design our component, taking into ...
Y. Benhadda, A. Hamid, T. Lebey
doaj   +1 more source

Unifying Models for Multiphase Coupled Inductors [PDF]

, 2020
This paper presents a unified model for multiphase coupled inductors. By summarizing and comparing three different ways of modeling multiphase coupled inductors, including a) an inductance matrix model derived based on self and mutual inductances; b) a multiwinding transformer model derived based on magnetizing and ...
Minjie Chen, Charles R. Sullivan
openaire   +1 more source