NMR Line Shapes and Multi-State Binding Equilibria [PDF]
, 2012 Biological function of proteins relies on conformational transitions and binding of specific ligands. Protein-ligand interactions are thermodynamically and kinetically coupled to conformational changes in protein structures as conceptualized by the ...
Kovrigin, Evgeni
core +1 more source
A Scaling Law to Predict the Finite-Length Performance of Spatially-Coupled LDPC Codes
, 2015 Spatially-coupled LDPC codes are known to have excellent asymptotic properties. Much less is known regarding their finite-length performance. We propose a scaling law to predict the error probability of finite-length spatially-coupled ensembles when ...
Olmos, Pablo M., Urbanke, Rüdiger
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Engineering Topological Nodal Line Semimetals in Rashba Spin-Orbit Coupled Atomic Chains
Condensed Matter, 2019 In this paper, we study an atomic chain in the presence of modulated charge potential and modulated Rashba spin-orbit coupling (RSOC) of equal periods.
Paola Gentile +4 more
doaj +1 more source
Simplifying Algebra in Feynman Graphs, Part III: Massive Vectors
, 2001 A T-dualized selfdual inspired formulation of massive vector fields coupled to arbitrary matter is generated; subsequently its perturbative series modeling a spontaneously broken gauge theory is analyzed.
A. Ferber +53 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Coupled-Mode Analysis of Line Parameters of Coupled Microstrip Lines [PDF]
Progress In Electromagnetics Research, 1999 M. Matsunaga, M. Katayama, K. Yasumoto
openaire +1 more source
Reflectionless CMV matrices and scattering theory
, 2014 Reflectionless CMV matrices are studied using scattering theory. By changing a single Verblunsky coefficient a full-line CMV matrix can be decoupled and written as the sum of two half-line operators. Explicit formulas for the scattering matrix associated
Chu, Sherry +2 more
core +1 more source