Results 81 to 90 of about 2,903,325 (300)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Spectral Signatures of Exceptional Points and Bifurcations in the Fundamental Active Photonic Dimer [PDF]
, 2017 The fundamental active photonic dimer consisting of two coupled quantum well lasers is investigated in the context of the rate equation model. Spectral transition properties and exceptional points are shown to occur under general conditions, not ...
Bountis, Tassos +2 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Electrically-Coupled Goubau-Line-Based Wireless Power Transfer System
IEEE Access, 2019 The first end-to-end Goubau-line-based wireless power transfer system with high efficiency is demonstrated in this paper. The wide spatial distribution of its electromagnetic fields and the lack of significant radiation are two of the most desirable ...
Brian J. Vaughn +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Quality factor of a transmission line coupled coplanar waveguide resonator
EPJ Quantum Technology, 2018 We investigate analytically the coupling of a coplanar waveguide resonator to a coplanar waveguide feedline. Using a conformal mapping technique we obtain an expression for the characteristic mode impedances and coupling coefficients of an asymmetric ...
Ilya Besedin, Alexey P Menushenkov
doaj +1 more source
Many Body Physics with Coupled Transmission Line Resonators
, 2012 We present the Josephson junction intersected superconducting transmission line resonator. In contrast to the Josephson parametric amplifier, Josephson bifurcation amplifier and Josephson parametric converter we consider the regime of few microwave ...
Hartmann, Michael J., Leib, Martin
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source