Results 91 to 100 of about 1,058,541 (299)

Energy efficient homes for rodent control across cityscapes

Environmental Research Letters
Cities spend millions of dollars on rodent mitigation to reduce public health risks. Despite these efforts, infestations remain high and distressing. Rodents thrive in the built environment in part due to reduced natural predators and their exploitation ...
Gabriel I Gadsden, Kristy M Ferraro, Nyeema C Harris   +2 more
doaj   +1 more source

Three decades of forest harvesting along a suburban–rural continuum

Ecosphere, 2017
Timber harvest is an important ecological disturbance that influences species composition, understory conditions, stand structure and growth, and carbon dynamics. Regional variation in harvest regimes and the associated ecological consequences are linked
David B. Kittredge, Jonathan R. Thompson, Luca L. Morreale, Anne G. Short Gianotti, Lucy R. Hutyra   +4 more
doaj   +1 more source

Even at the uttermost ends of the Earth: how seabirds telecouple the Beagle Channel with regional and global processes that affect environmental conservation and socio-ecological sustainability [PDF]

, 2017
Human-wildlife dynamics exhibit novel characteristics in the Anthropocene, given the unprecedented degree of globalization that has increased the linkages between habitats and people across space and time. This is largely caused by transnational mobility
Anderson, Christopher Brian, Huettmann, Falk, Pizarro Pinochet, Jose Cristobal, Raya Rey, Andrea Nélida   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

β-Barrel scaffolds for the grafting of extracellular loops from G-protein-coupled receptors [PDF]

, 2017
Owing to the difficulties in production and purification of G-protein-coupled receptors (GPCRs), relatively little structural information is available about this class of receptors.
Kleinschmidt, Jörg H., Skerra, Arne, Walser, Reto, Zerbe, Oliver   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Impact of seasonal forecast use on agricultural income in a system with varying crop costs and returns: an empirically-grounded simulation

Environmental Research Letters, 2017
Access to seasonal climate forecasts can benefit farmers by allowing them to make more informed decisions about their farming practices. However, it is unclear whether farmers realize these benefits when crop choices available to farmers have different ...
T Gunda, J T Bazuin, J Nay, K L Yeung
doaj   +1 more source

Global aging: emerging challenges [PDF]

, 2009
This repository item contains a single issue of The Pardee Papers, a series papers that began publishing in 2008 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.
Crampton, Alexandra
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Reframing the payments for ecosystem services framework in a coupled human and natural systems context: strengthening the integration between ecological and human dimensions

Ecosystem Health and Sustainability, 2017
Introduction: As challenges to biodiversity mount, land-use policies have been implemented to balance human needs and the integrity of ecological systems.
Rebecca L. Lewison, Li An, Xiaodong Chen
doaj   +1 more source