Results 101 to 110 of about 1,058,541 (299)

Dwelling Quietly in the Rich Club: Brain Network Determinants of Slow Cortical Fluctuations

, 2015
For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/functional phenomena that emerge from these underlying features.
Breakspear, Michael, Gollo, Leonardo L., Heuvel, Martijn van den, Hutchison, R. Matthew, Zalesky, Andrew   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Frontiers in socio-environmental research: components, connections, scale, and context

Ecology and Society, 2018
The complex and interdisciplinary nature of socio-environmental (SE) problems has led to numerous efforts to develop organizing frameworks to capture the structural and functional elements of SE systems. We evaluate six leading SE frameworks, i.e., human
Simone Pulver, Nicola Ulibarri, Kathryn L. Sobocinski, Steven M. Alexander, Michelle L. Johnson, Paul F. McCord, Jampel Dell'Angelo   +6 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

The modeling framework of the coupled human and natural systems in the Yellow River Basin

Geography and Sustainability
A mechanistic understanding and modeling of the coupled human and natural systems (CHANS) are frontier of geographical sciences and essential for promoting regional sustainability.
Shan Sang, Yan Li, Shuang Zong, Lu Yu, Shuai Wang, Yanxu Liu, Xutong Wu, Shuang Song, Xuhui Wang, Bojie Fu   +9 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Unveiling Interaction Patterns and Drivers of Coupled Human and Natural Systems: A Case Study of Beijing

Ecosystem Health and Sustainability
Understanding the interaction patterns of coupled human and natural systems (CHANS) is essential for sustainable urban development. However, existing studies have often failed to categorize interaction patterns based on variations in CHANS, which may ...
Kaiping Wang, Xin Liu, Xinyao Zhao, Tingwei Liu, Leqi Zhang, Lifu Zheng, Yunlu Zhang   +6 more
doaj   +1 more source

Local institutions and Natural Resource Management [PDF]

As researchers and policy-makers confront the challenges of and opportunities for improving natural resource management, increasing attention is being given to the dynamics of coupled natural-human systems.
Bell, Kathleen P., Leahy, Jessica, Snell, Margaret   +2 more
core   +1 more source