Results 51 to 60 of about 1,058,541 (299)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Who let the dog out? Dog owner attitudes and economics regulate the potential negative impact of domestic dogs on wildlife in a reserve network

Conservation Science and Practice
Many domestic animals have a profound impact on endangered species through complex interactions and spillover effects in and between coupled human and natural systems.
Yue Weng, William Joseph McShea, Hongbo Yang, Zhuojin Zhang, Weiming Lin, Fang Wang   +5 more
doaj   +1 more source

Modelling and simulating change in reforesting mountain landscapes using a social-ecological framework [PDF]

, 2010
Natural reforestation of European mountain landscapes raises major environmental and societal issues. With local stakeholders in the Pyrenees National Park area (France), we studied agricultural landscape colonisation by ash (Fraxinus excelsior) to ...
A Gibon, A Gibon, A Gibon, A Mottet, A Otte, Annick Gibon, BJ Fu, BL Turner II, C Fontaine, C Lundstrom, C Monteil, Claude Monteil, CS Holling, D Valbuena, David Sheeren, DC Parker, DC Parker, DG Brown, E Moreira, E Tasser, EJJ Rykiel, F Berkes, F Berkes, F Bousquet, F Bousquet, G Augustins, G Balent, Gérard Balent, J Brandt, J Kolasa, J Wu, JB Dent, JC Castella, JG Wu, JP Deffontaines, K Helming, L An, M Antrop, M Burgi, M Duru, M Duru, M Gellrich, M Muraz, MG Turner, MP Julien, N Andrieu, P Wardle, PH Verburg, QB Le, R Matthews, R Soliva, RB Matthews, RH Økland, RW Kates, S Wagner, SM Manson, Sylvie Ladet, T Berger, T Plieninger, T Streifeneder, TFH Allen, TJ Bontkes, TR Robinson, V Grimm, Z Naveh   +64 more
core   +5 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The physics of spreading processes in multilayer networks [PDF]

, 2016
The study of networks plays a crucial role in investigating the structure, dynamics, and function of a wide variety of complex systems in myriad disciplines.
A Cardillo, A Hackett, A Halu, A Lima, A Sole-Ribalta, A Solé-Ribalta, Alex Arenas, B Min, B Min, C Granell, C Granell, Clara Granell, D Brockmann, D Krioukov, D F Gleich, E Bullmore, E Cozzo, E Cozzo, F Battiston, F Radicchi, F Radicchi, F Sorrentino, F Tan, FR K Chung, G Bianconi, G Bianconi, G Menichetti, G J Baxter, I Abraham, I de Sola Pool, J Gao, J Gómez-Gardenes, J Gómez-Gardeñes, J Sanz, K-M Lee, L Bargigli, L Gauvin, L Sola, L Zhao, M Asllani, M Barthelemy, M Bazzi, M De Domenico, M De Domenico, M De Domenico, M De Domenico, M De Domenico, M De Domenico, M Dickison, M Kivelä, M Salehi, Manlio De Domenico, Mason A. Porter, ME J Newman, M A Porter, N Kouvaris, O Sporns, P Echenique, P J Mucha, R Gallotti, R Gallotti, R Guimerà, R Sevilla-Escoboza, R G Morris, S Boccaletti, S Boccaletti, S Funk, S Funk, S Gómez, S Wasserman, S-W Son, S D Reis, S V Buldyrev, T G Kolda, T P Peixoto, U Braun, V Nicosia, V Nicosia, X Zhang, Y Tang, Z Wang, Z Wang, Z Wu   +82 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Evacuation Plans and Simulations for Crowd Egress – A Review [PDF]

, 2018
Due to growing population density and increasing complexity and congestion of human habitat evacuation planning is essential to avoid major loss of life during a natural or un-natural disaster.
Goyal, P. (Purva), Saxena, A. (Akash)
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A Solution to Treat Mixed-Type Human Datasets from Socio-Ecological Systems

Journal of Environmental Geography, 2020
Coupled human and natural systems (CHANS) are frequently represented by large datasets with varied data including continuous, ordinal, and categorical variables. Conventional multivariate analyses cannot handle these mixed data types.
Clark Lisa B., González Eduardo, Henry Annie L., Sher Anna A.   +3 more
doaj   +1 more source

Biophysical and socioeconomic drivers of oil palm expansion in Indonesia

Environmental Research Letters, 2021
Indonesia has been the largest supplier of palm oil since 2007, and now supplies around 56% of the global market. While the existing literature has paid serious attention to the diverse impacts of oil palm plantation on socioeconomic factors and the ...
Yu Xin, Laixiang Sun, Matthew C Hansen
doaj   +1 more source