Results 71 to 80 of about 1,058,541 (299)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Moving sociohydrology forward: a synthesis across studies [PDF]
Hydrology and Earth System Sciences, 2015 Sociohydrology is the study of coupled human–water systems, building on the premise that water and human systems co-evolve: the state of the water system feeds back onto the human system, and vice versa, a situation denoted as "two-way coupling".
T. J. Troy +3 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
The Self-Organization of Speech Sounds [PDF]
, 2005 The speech code is a vehicle of language: it defines a set of forms used by a community to carry information. Such a code is necessary to support the linguistic interactions that allow humans to communicate. How then may a speech code be formed prior to
Oudeyer, Pierre-Yves
core +3 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
State-level variation drives wolf management in the northwestern United States
Environmental Research: EcologyRecovered and recovering carnivore populations in Europe and North America can pose risks to some human livelihoods like livestock ranching. These risks can motivate wildlife managers to lethally remove carnivores—decisions that are often controversial ...
Leandra Merz +6 more
doaj +1 more source
Reflooding the coupled human and natural system of the Waza-Logone Floodplain, Cameroon
Frontiers in Conservation ScienceThe rewilding framework is used to guide the restoration of ecological processes in natural systems, but the framework can also be used in the restoration of social and ecological processes in coupled human and natural systems.
Mark Moritz +2 more
doaj +1 more source
From concept to practice to policy: modeling coupled natural and human systems in lake catchments
Ecosphere, 2018 Recent debate over the scope of the U.S. Clean Water Act underscores the need to develop a robust body of scientific work that defines the connectivity between freshwater systems and people.
Kelly M. Cobourn +20 more
doaj +1 more source
Toward a Science of Sustainability [PDF]
, 2012 This report presents an overview of research horizons in sustainability science. Its motivation is to help harness science and technology to foster a transition toward sustainability – toward patterns of development that promote human well-being while ...
Clark, William C., Levin, Simon A.
core