Results 81 to 90 of about 1,058,541 (299)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
On production and abatement time scales in sustainable development. Can we loosen the sustainability screw ? [PDF]
In this paper we carry out a preliminary exploration of a time scales' conjecture, which postulates that "reasonable" notions of sustainability must include a suitable synchronisation of time scales of both the processes of human development and those of
AGRAWAL, Manju +2 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Wicked but worth it: student perspectives on socio-hydrology [PDF]
, 2016 harvestPolicy AnalysisMulti Actor ...
Bach +36 more
core +1 more source
Understanding the coupled natural and human systems in Dryland East Asia
Environmental Research Letters, 2012 Stressors including regional climate change, economic development effects upon land use and an increasing demand for food production have resulted in significant impacts on the dryland ecosystems in the East Asia (DEA) region. Ecosystem services, such as its provisional services in providing forage for grazing as well as its functional services in ...
Jiaguo Qi +3 more
openaire +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Pathways to the Future: Community Dialogues on Adaptive Environmental Management Through Scenario Projection in Google Maps [PDF]
This paper presents research on the potential of interactive media for regional community dialogues on future uncertainties and complexities in coupled human and natural systems.
Janssen, R. +4 more
core +1 more source
The Earth as an Engineering System: Addressing Sustainability through Science, Technology and Policy [PDF]
, 2012 We combine insights from the two emerging fields of engineering systems and sustainability science to develop an analytical approach for understanding and managing coupled natural and human systems. The Earth system is characterized with reference to the
Friedman, Carey L., Selin, Noelle Eckley
core
Modeling economic systems as locally-constructive sequential games [PDF]
, 2017 Real-world economies are open-ended dynamic systems consisting of heterogeneous interacting participants. Human participants are decision-makers who strategically take into account the past actions and potential future actions of other participants.
Tesfatsion, Leigh, Tesfatsion, Leigh
core +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source