Results 61 to 70 of about 43,191 (254)

Optimizing Rebar Consumption and Cutting Waste in Column Reinforcement: Integrated Mechanical Couplers and a Special-Length-Priority Minimization Algorithm

Buildings
The construction of reinforced concrete (RC) structures inevitably consumes an excessive number of rebars, leading to significant cutting waste and carbon emissions.
Daniel Darma Widjaja, Sunkuk Kim, Dong-Jin Kim   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A 77-GHz Six-Port Sensor for Accurate Near-Field Displacement and Doppler Measurements

Sensors, 2018
A continuous-wave (CW) radar sensor design based on a millimetre-wave six-port interferometer is proposed. A complete sensor prototype is conceived of, fabricated and measured at 77 GHz for short-range professional and industrial applications.
Homa Arab, Steven Dufour, Emilia Moldovan, Cevdet Akyel, Serioja O. Tatu   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

An investigation of the polarization dependence of a temperature sensor based on an optical microfiber coupler

The dependence on polarization of the performance of a microfiber coupler based temperature sensor is experimentally investigated. The optical microfiber coupler based temperature sensor has a diameter circa 2µm and can sense temperature in the range ...
Bo, L., Farrell, G., Semenova, Y., Brambilla, G., Wang, Pengfei   +4 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A compact two-dimensional grating coupler used as a polarization splitter

, 2003
We demonstrate a novel polarization splitter based on a two-dimensional grating etched in a silicon-on-insulator waveguide. The device couples orthogonal modes from a single-mode optical fiber into identical modes of two planar ridge waveguides.
De La Rue, RM, Baets, Roel, De La Rue, R.M., Baets, R, FRANDSEN, L, Tailaert, D., Frandsen, LH, Borel, Peter Ingo, BOREL, P, Taillaert, Dik, DE LA RUE, R, Rue, R.M. de la, Taillaert, Dirk, Frandsen, L.H., Taillaert, D, Chong, H, Chong, H., Baets, R., Borel, PI, Frandsen, Lars Hagedorn, Taillaert, D., Borel, P.I.   +21 more
core   +1 more source