Results 121 to 130 of about 215,407 (319)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Antiferromagnetic Dimers of Ni(II) in the S=1 Spin-Ladder Na_2Ni_2(C_2O_4)_3(H_2O)_2

, 2006
We report the synthesis, crystal structure and magnetic properties of the S=1 2-leg spin-ladder compound Na_2Ni_2(C_2O_4)_3(H_2O)_2. The magnetic properties were examined by magnetic susceptibility and pulsed high field magnetization measurements.
A. Abragam, B. Büchner, C. Dahl, C. Golze, C. Mennerich, D. J. Price, D. J. Price, F. J. Litterst, H. Rakoto, H.-H. Klauss, J. Kreitlow, J.-M. Broto, M. Broekelmann, M. Goiran, M. Takahashi, O. Kataeva, R. Carlin, R. Klingeler, S.-N. Grossjohann, T. Takeuchi, V. Kataev, W. Brenig   +21 more
core   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Spin wave stiffness and exchange stiffness of doped permalloy via ab-initio calculation

, 2019
The way doping affects the spin wave stiffness and the exchange stiffness of permalloy (Py) is investigated via ab-initio calculations, using the Korringa-Kohn-Rostoker (KKR) Green function formalism.
Ebert, Hubert, Mankovsky, Sergey, Sipr, Ondrej   +2 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Coupling coordination degree of healthcare resource supply, demand and elderly population change in China

International Journal for Equity in Health
To analyze the trend of the coupling and coordination of the supply and demand of healthcare resources between the elderly population and healthcare resources in China during the period of 2012–2022, to reveal the impact of the growth of the elderly ...
Mengyuan Ma, Leiyu Shi, Wanzhen Xie, Qiuli Zhu, Junqing Luo, Shengwu Liao, Oudong Xia, Gang Sun   +7 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Study on the coupling and coordination relationship between health resource allocation and economic development level in Shanxi province

Huli yanjiu
ObjectiveTo analyze the coupling and coordination degree and relative development degree of health resources and economic development in Shanxi province from 2017 to 2021, and to provide reference for promoting the coordinated development of health ...
WANG Xueyang, YAN Yingying, DUAN Zhaoxia
doaj  

Study on the evaluation of cross-border e-commerce and logistics synergy in Chongqing based on coupled coordination degree model

Academic Journal of Management and Social Sciences, 2023
The article firstly constructs a comprehensive evaluation index system for the two systems of cross-border e-commerce and cross-border logistics, and then conducts an empirical analysis of the coupling coordination level based on the data samples of cross-border e-commerce and cross-border logistics in Chongqing city from 2016-2021 by using the entropy
openaire   +1 more source