Results 51 to 60 of about 4,486,936 (248)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Coupling efficiency of a partially coherent collimating laser from turbulent biological tissue to fiber

Results in Physics, 2019
We propose a model of the fiber coupling efficiency for a partially coherent collimating laser beam propagating through turbulent biological tissue to fiber.
Qiyong Liang, Beibei Hu, Yixin Zhang, Yun Zhu, Shibao Deng, Lin Yu   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The influence of training status, age, and muscle fiber type on cycling efficiency and endurance performance. [PDF]

, 2013
The purpose of this study was to assess the influence of age, training status, and muscle fiber-type distribution on cycling efficiency. Forty men were recruited into one of four groups: young and old trained cyclists, and young and old untrained ...
Wiles, J., Hopker, J., Coleman, Damian A, Jobson, Simon A., Gregson, Hannah C, Wiles, Jonathan, Coleman, D., Gregson, H., Coleman, Damian A., Hopker, James G., Passfield, L., von der Haar, Tobias, Passfield, Louis, Von der Haar, T., Jobson, S., Gregson, Hannah C.   +15 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigation on the Coupling of Vortex Beam Into Parabolic Fiber in Turbulent Atmosphere

IEEE Photonics Journal, 2019
Aiming at the demand for high-capacity wireless-fiber link, the coupling efficiency of Laguerre Gaussian (LG) vortex beam into parabolic fiber under atmospheric turbulence is first investigated.
Lin Yu, Yixin Zhang
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Surface plasmon coupling dynamics in InGaN/GaN quantum-well structures and radiative efficiency improvement [PDF]

, 2014
Surface plasmonics from metal nanoparticles have been demonstrated as an effective way of improving the performance of low-efficiency light emitters. However, reducing the inherent losses of the metal nanoparticles remains a challenge.
Iida, Daisuke, Ou, Haiyan, Fadil, Ahmed, Petersen, Paul Michael, Ma, J, Fadil, A, Ou, YY, Chen, Yuntian, Chen, YT, Iida, D, Petersen, PM, Ma, Jun, Ou, Yiyu, Ou, HY   +13 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

National Action Plan for Energy Efficiency, Chapter 6: Energy Efficiency Program Best Practices

, 2006
Chapter from the National Action Plan for Energy Efficiency documenting key findings from energy efficiency programs that have been successfully operating for many ...
National Action Plan for Energy Efficiency (U.S.)
core