Results 91 to 100 of about 1,440,973 (285)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Universal damping mechanism of quantum vibrations in deep sub-barrier fusion reactions

EPJ Web of Conferences, 2017
I demonstrate that the coordinate dependence of the coupling strengths of colliding nuclei is important for describing the deep sub-barrier fusion hindrance.
Ichikawa Takatoshi
doaj   +1 more source

Spin pumping in strongly coupled magnon-photon systems

, 2016
We experimentally investigate magnon-polaritons, arising in ferrimagnetic resonance experiments in a microwave cavity with a tuneable quality factor.
Goennenwein, Sebastian T. B., Gross, Rudolf, Harder, Michael, Huebl, Hans, Maier-Flaig, Hannes   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Greybody factor for an electrically charged regular-de Sitter black holes in d-dimensions

European Physical Journal C: Particles and Fields
We investigate the propagation of scalar fields in the gravitational background of higher-dimensional, electrically charged, regular de Sitter black holes.
Md Sabir Ali, A. Naveena Kumara, Kartheek Hegde, C. L. Ahmed Rizwan, Shreyas Punacha, K. M. Ajith   +5 more
doaj   +1 more source

Efficiency Analysis of Wireless Power Transmission for Portable Electronics

MATEC Web of Conferences, 2015
With the portable electronics becoming more and more popular, a model of wireless power transmission for general portable electronics was presented based on the principles of magnetic resonance transmission.
Xu Xingping, Yu Chuanxiang, Zhang Yuxin, Zhang Man, Hu Haotian   +4 more
doaj   +1 more source

Comment on the frozen QCD coupling

, 2013
The frozen QCD coupling is a parameter often used as an effective fixed coupling. It is supposed to mimic both the running coupling effects and the lack of knowledge of alpha_s in the infrared region.
Ermolaev, B. I., Greco, M., Troyan, S. I.   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source