Results 121 to 130 of about 1,440,973 (285)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Quantifying the pyroelectric and photovoltaic coupling series of ferroelectric films

Nature Communications
The coupling of photovoltaic and pyroelectric effects is a common phenomenon in ferroelectric films and often results in coupling enhancements. Although the coupling effects of a variety of ferroelectric films have been examined in terms of improved ...
Chaosheng Hu, Xingyue Liu, Huiyu Dan, Chong Guo, Maoyi Zhang, Chris R. Bowen, Ya Yang   +6 more
doaj   +1 more source

Charactering Neural Spiking Activity Evoked by Acupuncture Through Coupling Generalized Linear Model

Entropy
Acupuncturing the ST36 acupoint can evoke a responding activity in the spinal dorsal root ganglia and generate spikes. In order to identify the responding mechanism of different acupuncture manipulations, in this paper the spike history of neurons is ...
Qing Qin, Kaiyue Zhang, Yanqiu Che, Chunxiao Han, Yingmei Qin, Shanshan Li   +5 more
doaj   +1 more source

Mode-coupling branches in single-mode classical Rayleigh-Taylor instability for arbitrary Atwood numbers

Results in Physics, 2019
In this research, the effect of the mode-coupling branches/channels on harmonic amplitudes in single-mode classical Rayleigh-Taylor instability for arbitrary Atwood numbers in the weakly nonlinear stage is investigated by employing the tracking ...
Wanhai Liu (刘万海), Yulian Chen (陈玉莲), Yumei Huang, Yang Mei, Wenhua Ye (叶文华)   +4 more
doaj   +1 more source

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters. [PDF]

J Med Chem, 2022
Kiefer AF, Bousis S, Hamed MM, Diamanti E, Haupenthal J, Hirsch AKH.   +5 more
europepmc   +1 more source

Electron impact excitation cross sections for allowed transitions in atoms

, 1995
We present a semiempirical Gaunt factor for widely used Van Regemorter formula [Astrophys. J. 136, 906 (1962)] for the case of allowed transitions in atoms with the LS coupling scheme. Cross sections calculated using this Gaunt factor agree with measured
A. Chutjian, A. K. Pradhan, A. Mahan, A. Van Raan, D. Cartwring, D. H. Crandall, D. H. Sampson, D. Leep, D. Leep, D. Rall, D. Sampson, D. Shemansky, D. Spence, E. Enemark, E. Stone, E. Stone, E. Zipf, F. A. Sharton, F. Donaldson, H. A. Bethe, H. Mousa, H. Van Regemorter, I. Bogdanova, I. I. Sobelman, I. I. Sobelman, I. P. Zapesochnyi, I. Zapesochnyi, J. Doering, J. Jobe, J. K. Ballou, J. Showalter, J. W. McConkey, M. Dillon, R. D. Cowan, R. Hall, R. Jonh, R. Long, R. Mewe, R. S. Schappe, S. Chen, S. M. Younger, S. Wang, V. P. Shevelko, W. Westerveld, W. Williams   +44 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Possible Role of Dentin as a Piezoelectric Signal Generator by Determining the Elec-tromechanical Coupling Factor of Dentin

Dental Hypotheses, 2011
Introduction: This article aimed at calculation of the electromechanical coupling factor of dentin which is an indicator of the effectiveness with which a piezoelectric material converts electrical en-ergy into mechanical energy, or vice versa.
Atabak Shahidi
doaj  

Enhancing the Out-Coupling Efficiency of Organic Light-Emitting Diodes Using Two-Dimensional Periodic Nanostructures

Advances in Materials Science and Engineering, 2012
The out-coupling efficiency of planar organic light emitting diodes (OLEDs) is only about 20% due to factors, such as, the total internal reflection, surface plasmon coupling, and metal absorption.
Qingyang Yue, Wei Li, Fanmin Kong, Kang Li   +3 more
doaj   +1 more source

Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor. [PDF]

Pharmaceutics, 2021
Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch AKH, Fuhrmann G.   +8 more
europepmc   +1 more source