Results 91 to 100 of about 6,778,426 (314)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Broadband Phonon Resonance Spectrum in Host–Guest Resonator Arrays via Nonlocal Coupling

Small Structures
Resonance mechanisms offer a promising way to control phonon transport at the nanoscale, but realization of broadband phonon resonance remains challenging due to the narrow band nature of individual resonators.
Shuang Lu, Zhongwei Zhang, Rui Ma, Yuxing Wang, Yong Li, Jie Chen   +5 more
doaj   +1 more source

Subthalamic nucleus phase–amplitude coupling correlates with motor impairment in Parkinson’s disease

Clinical Neurophysiology, 2016
Highlights • We obtained invasive subthalamic nucleus recordings in 33 Parkinson’s disease patients.• Phase–amplitude coupling between beta band and high-frequency oscillations correlates with severity of motor impairments.• Parkinsonian pathophysiology ...
B. V. van Wijk, M. Beudel, A. Jha, A. Oswal, T. Foltynie, M. Hariz, P. Limousin, L. Zrinzo, T. Aziz, A. Green, P. Brown, V. Litvak   +11 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on Fluid-Structure Coupling Vibration of Compressor Pipeline

Shock and Vibration, 2019
In practical engineering, pipeline vibration is often not caused by a single factor but by a combination of many factors. A fluid-structure coupling method is proposed in this paper and used to study the vibration of the compressor pipeline under the ...
Jia Wu, Chunjie Li, Shuiying Zheng, Jingheng Gao   +3 more
doaj   +1 more source

Influence of coupling topology and noise on the possibility of frequency tuning in ensembles of FitzHugh–Nagumo oscillators [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
Purpose. The study focuses on analyzing spike activity and synchronization in ensembles of FitzHugh–Nagumo neurons, both with and without external noise excitation. In these networks oscillations at different frequencies can be induced depending on
Новичкова, Валентина Алексеевна, Rybalova, E. V., Ponomarenko, Vladimir Ivanovich, Vadivasova, Tatjana Evgenevna   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Mitigating mutual coupling effects on circular polarization for improved bandwidth in MIMO systems: A novel approach

Heliyon
An improved mutual coupling compensation in circularly polarized (CP) multi-input multi-output (MIMO) dielectric resonator antenna (DRA) is presented in this paper.
A. Ali, M.N.M. Yasin, I. Adam, A.M. Ismail, S.P. Jack, Abdullah Alghaihab, N.I.M. Nor, N.A.A. Rahman   +7 more
doaj   +1 more source

A Computational Study on the Magnetic Resonance Coupling Technique for Wireless Power Transfer

MATEC Web of Conferences, 2017
Non-radiative wireless power transfer (WPT) system using magnetic resonance coupling (MRC) technique has recently been a topic of discussion among researchers.
Zakaria N.A., Jusoh M., Ghazali N.H., Yasin M.N., Sabapathy T., Osman M.N., Ahmad N., Zakaria M.Z.   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source