Results 91 to 100 of about 524,705 (296)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Three-dimensional negative index of refraction at optical frequencies by coupling plasmonic waveguides

, 2010
We identify a route towards achieving a negative index of refraction at optical frequencies based on coupling between plasmonic waveguides that support backwards waves.
de Waele, René, Kuipers, L., Polman, Albert, Verhagen, Ewold   +4 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Quasinormal modes and quantization of area/entropy for noncommutative BTZ black hole

European Physical Journal C: Particles and Fields, 2018
We investigate the quasinormal modes and area/entropy spectrum for the noncommutative BTZ black hole. The exact expressions for QNM frequencies are presented by expanding the noncommutative parameter in horizon radius.
Lu Huang, Juhua Chen, Yongjiu Wang
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Strong coupling of collective intermolecular vibrations in organic materials at terahertz frequencies

Nature Communications, 2019
Here, the authors demonstrate strong coupling between collective, terahertz inter-molecular vibrations of organic materials and a Fabry-Pérot cavity. These results extend the applicability of polaritonic chemistry to large-scale organic systems, such as ...
Ran Damari, Omri Weinberg, Daniel Krotkov, Natalia Demina, Katherine Akulov, Adina Golombek, Tal Schwartz, Sharly Fleischer   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Inelastic Scattering from Local Vibrational Modes

, 2008
We study a nonuniversal contribution to the dephasing rate of conduction electrons due to local vibrational modes. The inelastic scattering rate is strongly influenced by multiphonon excitations, exhibiting oscillatory behaviour.
Dóra, Balázs, Gulácsi, Miklós
core   +1 more source

Broadband Phonon Resonance Spectrum in Host–Guest Resonator Arrays via Nonlocal Coupling

Small Structures
Resonance mechanisms offer a promising way to control phonon transport at the nanoscale, but realization of broadband phonon resonance remains challenging due to the narrow band nature of individual resonators.
Shuang Lu, Zhongwei Zhang, Rui Ma, Yuxing Wang, Yong Li, Jie Chen   +5 more
doaj   +1 more source

Genuine cross-frequency coupling networks in human resting-state electrophysiological recordings.

PLoS Biology, 2020
Phase synchronization of neuronal oscillations in specific frequency bands coordinates anatomically distributed neuronal processing and communication. Typically, oscillations and synchronization take place concurrently in many distinct frequencies, which
Felix Siebenhühner, Sheng H Wang, Gabriele Arnulfo, Anna Lampinen, Lino Nobili, J Matias Palva, Satu Palva   +6 more
doaj   +1 more source