Results 101 to 110 of about 524,705 (296)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Study on Fluid-Structure Coupling Vibration of Compressor Pipeline

Shock and Vibration, 2019
In practical engineering, pipeline vibration is often not caused by a single factor but by a combination of many factors. A fluid-structure coupling method is proposed in this paper and used to study the vibration of the compressor pipeline under the ...
Jia Wu, Chunjie Li, Shuiying Zheng, Jingheng Gao   +3 more
doaj   +1 more source

Influence of coupling topology and noise on the possibility of frequency tuning in ensembles of FitzHugh–Nagumo oscillators [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
Purpose. The study focuses on analyzing spike activity and synchronization in ensembles of FitzHugh–Nagumo neurons, both with and without external noise excitation. In these networks oscillations at different frequencies can be induced depending on
Новичкова, Валентина Алексеевна, Rybalova, E. V., Ponomarenko, Vladimir Ivanovich, Vadivasova, Tatjana Evgenevna   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mitigating mutual coupling effects on circular polarization for improved bandwidth in MIMO systems: A novel approach

Heliyon
An improved mutual coupling compensation in circularly polarized (CP) multi-input multi-output (MIMO) dielectric resonator antenna (DRA) is presented in this paper.
A. Ali, M.N.M. Yasin, I. Adam, A.M. Ismail, S.P. Jack, Abdullah Alghaihab, N.I.M. Nor, N.A.A. Rahman   +7 more
doaj   +1 more source

A Computational Study on the Magnetic Resonance Coupling Technique for Wireless Power Transfer

MATEC Web of Conferences, 2017
Non-radiative wireless power transfer (WPT) system using magnetic resonance coupling (MRC) technique has recently been a topic of discussion among researchers.
Zakaria N.A., Jusoh M., Ghazali N.H., Yasin M.N., Sabapathy T., Osman M.N., Ahmad N., Zakaria M.Z.   +7 more
doaj   +1 more source

Phase-amplitude coupling and infraslow (<1Hz) frequencies in the rat brain: relationship to resting state fMRI

Frontiers in Integrative Neuroscience, 2014
Resting state functional magnetic resonance imaging (fMRI) can identify network alterations that occur in complex psychiatric diseases and behaviors, but its interpretation is difficult because the neural basis of the infraslow BOLD fluctuations is ...
Garth John Thompson, Wen-Ju ePan, Jacob C. W. Billings, Joshua Koehler Grooms, Sadia eShakil, Dieter eJaeger, Shella Dawn Keilholz   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Free vibrations of delaminated beams [PDF]

Free vibration of laminated composite beams is studied. The effect of interply delaminations on natural frequencies and mode shapes is evaluated both analytically and experimentally.
Grady, J. E., Shen, M.-H. H.
core   +1 more source

Multiple Frequencies in the Basal Ganglia in Parkinson's Disease

Advances in Electrical and Electronic Engineering, 2015
In recent years, the authors have developed what appears to be a very successful phenomenological model for analyzing the role of deep brain stimulation (DBS) in alleviating the symptoms of Parkinson's disease.
Clare M. Davidson, Annraoi M de Paor, Madeleine M. Lowery   +2 more
doaj   +1 more source