Results 171 to 180 of about 24,172 (336)

Flexible Pipes: Slug Flow and Structure Coupling

open access: yes, 2018
In this thesis, a computational scheme for coupled internal multiphase flow and structural dynamic of flexible pipes is presented and tested. The model consists of a 1D simulator based on a slug tracking model, and a 3D structural dynamic simulator based on lumped mass formulation.
openaire   +1 more source

Super‐Convergent Meshless Computations for Active Vibration Control of Bi‐Directional Functionally Graded Terfenol‐D Beams with Twisted Geometry

open access: yesAdvanced Theory and Simulations, EarlyView.
This study develops a superconvergent meshless method to analyze and control vibrations in twisted, bidirectional functionally graded Terfenol‐D beams. By optimizing magnetostrictive patch placement, it demonstrates effective vibration suppression under dynamic loads, highlighting the design potential of strategically graded materials in complex ...
Mukund A. Patil   +2 more
wiley   +1 more source

Paleoseismological evidence for segmentation of the Main Himalayan Thrust in the Darjeeling-Sikkim Himalaya. [PDF]

open access: yesSci Rep
Brice A   +8 more
europepmc   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

open access: yesAdvanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian   +15 more
wiley   +1 more source

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

open access: yesAdvanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang   +9 more
wiley   +1 more source

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

open access: yesAdvanced Science, EarlyView.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu   +12 more
wiley   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

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