Results 171 to 180 of about 3,068,177 (243)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Electroconvulsive Therapy for Severe Refractory Tardive Dystonia Without Active Depression: A Case Report. [PDF]

Neuropsychopharmacol Rep
Asahi T, Kawamata Y, Sugawara N, Maehara R, Yasui-Furukori N.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Motivational aspects among MEDical Students to Participate as first ResPONDer in out-of-hospital cardiac arrest (MEDSPOND): a pre-post educational intervention study. [PDF]

BMC Med Educ
Ganter J, Fiebelkorn L, Bansbach J, Bushuven S, Busch HJ, Buerkle H, Heinrich S.   +6 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Association of Plastic Surgeons of India Postgraduate Medical Education (APSI-PGME) Course: How Far Have We Reached?

Indian Journal of Plastic Surgery
Veena Kumari Singh, Ankur Bhatnagar, Ravi Mahajan, Vijay Kumar, Nitin Mokal, Hari Venkatramani   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Resource Use in Introductory Biology: Evaluating Latent Patterns, Demographic Covariates, and Effects on Final Course Grade. [PDF]

CBE Life Sci Educ
Weatherton M, Aikens M.
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Adherence to risk minimization measures for alemtuzumab use in multiple sclerosis: a drug utilization study in four European countries. [PDF]

Ther Adv Neurol Disord
de Keijzer C, E JY, Yang Q, Gitonga R, Hiller D, Jurgensen S, Salloum N, Cunha-Santos J, Hoogewys-Cynober E, Vinet L, Chirieac M, Benzerdjeb H, Thoene D, Ziemssen T, Drahota J, Horáková D, Brown W, Hobart J, Robertson NP, Hakkarainen KM, Sinnott SJ.   +20 more
europepmc   +1 more source