A Course Design for Remote Teaching Advanced Topics in Neuroscience. [PDF]
J Undergrad Neurosci Educ, 2022 Ramos R, Rivera-Rodriguez EJ.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Does design education always produce designers?
, 2011 By questioning what we mean by the term ‘designer’ this paper describes the ideas behind a new Open University course in Design Thinking. The paper shows how the creative skills of students can be consciously developed, and deliberately applied outside ...
Lloyd, Peter
core
An analysis of an industry sponsored governance development intervention : the case of Dairy NZ's Mark and Measure programme : a thesis presented in partial fulfilment of the requirements for the degree of Master of Business Studies in Management at Massey University, Palmerston North, New Zealand [PDF]
, 2014 Appendices 6 & 7 removed due to copyright reasonsA plethora of ‘good’ corporate governance prescriptions are ascribed to boards. Yet there is little research on the influence of corporate governance prescriptions on businesses.
Hunt, Michelle
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Classification of Features across Five CURE Networks Reveals Opportunities to Improve Course Design, Instruction, and Equity. [PDF]
J Microbiol Biol Educ, 2023 Burmeister AR, Bauer M, Graham MJ.
europepmc +1 more source
The Design, Implementation, and Assessment of a New Capstone Course Aimed at Science Education Majors [PDF]
, 2001 This paper rationalizes the selection of the concept of energy as the central theme of a new capstone course aimed at science education majors. It describes the goals of the course and the activities that preceded the course design and led to the ...
Arce, J., Betancourt, R.
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Online video course design of elliptic partial differential equation based on image high-resolution processing. [PDF]
Soft comput, 2023 Huang H.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source