Results 41 to 50 of about 47,262 (306)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Applying the Geodetic Adjustment Method for Positioning in Relation to the Swarm Leader of Underwater Vehicles Based on Course, Speed, and Distance Measurements

Energies, 2022
The research consisted of simulating the movement of a single vehicle in relation to the swarm leader on a square-shaped path, taking into account measurement errors characteristic of typical cheap navigation devices and the hydroacoustic system.
Krzysztof Naus, Paweł Piskur
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Use of Artificial Intelligence in Enhancing Navigation Safety in Case of GNSS Signal Fading or Interference [PDF]

TransNav
Global Navigation Satellite Systems (GNSS) play a key role in modern navigation and transportation service delivery. Today it is difficult to imagine the daily operation of land, sea or air transportation without the positioning and timing provided by ...
Marcin Chrzan
doaj   +1 more source

Design of data structures for terrain reference navigation [PDF]

, 1994
This thesis describes the design of a data structure for use with Digitised Terrain Elevation Data (DTED) in Terrain Reference Navigation (TRN) systems.
Gia, M. C., Gia, M
core  

Visibility Augmentation of the Proportional Navigation Guidance

, 2017
The paper presents a visibility augmentation method for a classical proportional navigation guidance law that helps the pursuer maintaining visual contact with the target, and also allows to recover loss of line-of-sight.
POLLINI, LORENZO, TARDIOLI, L., Giovanni Franzini, FRANZINI, GIOVANNI, Lorenzo Pollini, Luca Tardioli, Mario Innocenti, INNOCENTI, MARIO   +7 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Navigation Decision-Making Method in Estuary Deep Trough with Varying Width of Navigable Waters

Shanghai Jiaotong Daxue xuebao
To address the challenges of ship navigation decision-making in the water area where the navigable width of the estuary deep channel changes, taking the north channel deep waterway of the Yangtze River estuary as an example, research is conducted on the ...
HE Yixiong, DAI Yonggang, ZHAO Xingya, YU Deqing, HUANG Liwen
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Navigation-guided optic canal decompression for traumatic optic neuropathy: Two case reports

Indian Journal of Ophthalmology, 2018
Two cases of traumatic optic neuropathy presented with profound loss of vision. Both cases received a course of intravenous corticosteroids elsewhere but did not improve.
Kasturi Bhattacharjee, Samir Serasiya, Deepika Kapoor, Harsha Bhattacharjee   +3 more
doaj   +1 more source